4XOY

Crystal structure of ERK2 in complex with an inhibitor

Summary for 4XOY

Entry DOI	10.2210/pdb4xoy/pdb
Descriptor	Mitogen-activated protein kinase 1, 2-amino-1,9-dihydro-6H-purine-6-thione, SULFATE ION, ... (4 entities in total)
Functional Keywords	serine/threonine-protein kinase, transferase
Biological source	Rattus norvegicus (Norway Rat)
Cellular location	Cytoplasm, cytoskeleton, spindle : P63086
Total number of polymer chains	1
Total formula weight	41340.62
Authors	Gelin, M.,Allemand, F.,Labesse, G.,Guichou, J.F. (deposition date: 2015-01-16, release date: 2015-08-12, Last modification date: 2024-01-10)
Primary citation	Gelin, M.,Delfosse, V.,Allemand, F.,Hoh, F.,Sallaz-Damaz, Y.,Pirocchi, M.,Bourguet, W.,Ferrer, J.L.,Labesse, G.,Guichou, J.F. Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71:1777-1787, 2015 Cited by PubMed: 26249358 DOI: 10.1107/S1399004715010342 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation