6Y6V

p38a bound with MCP-81

Summary for 6Y6V

Entry DOI	10.2210/pdb6y6v/pdb
Descriptor	Mitogen-activated protein kinase 14, 5-azanyl-~{N}-[[4-[[5-~{tert}-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide (3 entities in total)
Functional Keywords	kinase, inhibitor, mapk14, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Mus musculus (House mouse)
Total number of polymer chains	1
Total formula weight	41942.86
Authors	Schroeder, M.,Roehm, S.,Knapp, S.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Structural Genomics Consortium (SGC) (deposition date: 2020-02-27, release date: 2020-03-11, Last modification date: 2024-01-24)
Primary citation	Rohm, S.,Schroder, M.,Dwyer, J.E.,Widdowson, C.S.,Chaikuad, A.,Berger, B.T.,Joerger, A.C.,Kramer, A.,Harbig, J.,Dauch, D.,Kudolo, M.,Laufer, S.,Bagley, M.C.,Knapp, S. Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208:112721-112721, 2020 Cited by PubMed: 33035818 DOI: 10.1016/j.ejmech.2020.112721 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation