1VYJ

Structural and biochemical studies of human PCNA complexes provide the basis for association with CDK/cyclin and rationale for inhibitor design

Summary for 1VYJ

Related1AXC 1U76 1U7B 1VYM 1W60
DescriptorPROLIFERATING CELL NUCLEAR ANTIGEN, SMALL PEPTIDE SAVLQKKITDYFHPKK (3 entities in total)
Functional Keywordsdna, replication, processivity, oncogene, dna-binding protein, dna replication, dna-binding systemic lupus erythematosus, dna binding protein
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus P12004
Total number of polymer chains12
Total molecular weight184224.11
Authors
Kontopidis, G.,Wu, S.,Zheleva, D.,Taylor, P.,Mcinnes, C.,Lane, D.,Fischer, P.,Walkinshaw, M.D. (deposition date: 2004-04-30, release date: 2005-01-13, Last modification date: 2011-07-13)
Primary citation
Kontopidis, G.,Wu, S.,Zheleva, D.,Taylor, P.,Mcinnes, C.,Lane, D.,Fischer, P.,Walkinshaw, M.D.
Structural and Biochemical Studies of Human Proliferating Cell Nuclear Antigen Complexes Provide a Rationale for Cyclin Association and Inhibitor Design
Proc.Natl.Acad.Sci.USA, 102:1871-, 2005
PubMed: 15681588 (PDB entries with the same primary citation)
DOI: 10.1073/PNAS.0406540102
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.260234.0%20.5%4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution