8QXA

TDP-43 amyloid fibrils: Morphology-1b

Summary for 8QXA

Entry DOI	10.2210/pdb8qxa/pdb
EMDB information	18716
Descriptor	TAR DNA-binding protein 43 (1 entity in total)
Functional Keywords	amyloidosis, protein misfolding disease, amyloid fibrils, cryo electron microscopy, amyloid key, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	12
Total formula weight	537416.90
Authors	Sharma, K.,Shenoy, J.,Loquet, A.,Schmidt, M.,Faendrich, M. (deposition date: 2023-10-24, release date: 2024-01-24)
Primary citation	Sharma, K.,Stockert, F.,Shenoy, J.,Berbon, M.,Abdul-Shukkoor, M.B.,Habenstein, B.,Loquet, A.,Schmidt, M.,Fandrich, M. Cryo-EM observation of the amyloid key structure of polymorphic TDP-43 amyloid fibrils. Nat Commun, 15:486-486, 2024 Cited by PubMed: 38212334 DOI: 10.1038/s41467-023-44489-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.05 Å)

Structure validation