8QXA

TDP-43 amyloid fibrils: Morphology-1b

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003723	molecular_function	RNA binding
A	0003730	molecular_function	mRNA 3'-UTR binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005726	cellular_component	perichromatin fibrils
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006397	biological_process	mRNA processing
A	0008289	molecular_function	lipid binding
A	0008380	biological_process	RNA splicing
A	0010467	biological_process	gene expression
A	0010468	biological_process	regulation of gene expression
A	0010494	cellular_component	cytoplasmic stress granule
A	0010629	biological_process	negative regulation of gene expression
A	0016607	cellular_component	nuclear speck
A	0031647	biological_process	regulation of protein stability
A	0032024	biological_process	positive regulation of insulin secretion
A	0034976	biological_process	response to endoplasmic reticulum stress
A	0035061	cellular_component	interchromatin granule
A	0042307	biological_process	positive regulation of protein import into nucleus
A	0042752	biological_process	regulation of circadian rhythm
A	0042802	molecular_function	identical protein binding
A	0042981	biological_process	regulation of apoptotic process
A	0043232	cellular_component	intracellular non-membrane-bounded organelle
A	0043922	biological_process	negative regulation by host of viral transcription
A	0048511	biological_process	rhythmic process
A	0051726	biological_process	regulation of cell cycle
A	0061158	biological_process	3'-UTR-mediated mRNA destabilization
A	0070935	biological_process	3'-UTR-mediated mRNA stabilization
A	0071765	biological_process	nuclear inner membrane organization
A	0097157	molecular_function	pre-mRNA intronic binding
A	0140693	molecular_function	molecular condensate scaffold activity
A	1990000	biological_process	amyloid fibril formation
B	0000785	cellular_component	chromatin
B	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
B	0001933	biological_process	negative regulation of protein phosphorylation
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003690	molecular_function	double-stranded DNA binding
B	0003723	molecular_function	RNA binding
B	0003730	molecular_function	mRNA 3'-UTR binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005726	cellular_component	perichromatin fibrils
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0006397	biological_process	mRNA processing
B	0008289	molecular_function	lipid binding
B	0008380	biological_process	RNA splicing
B	0010467	biological_process	gene expression
B	0010468	biological_process	regulation of gene expression
B	0010494	cellular_component	cytoplasmic stress granule
B	0010629	biological_process	negative regulation of gene expression
B	0016607	cellular_component	nuclear speck
B	0031647	biological_process	regulation of protein stability
B	0032024	biological_process	positive regulation of insulin secretion
B	0034976	biological_process	response to endoplasmic reticulum stress
B	0035061	cellular_component	interchromatin granule
B	0042307	biological_process	positive regulation of protein import into nucleus
B	0042752	biological_process	regulation of circadian rhythm
B	0042802	molecular_function	identical protein binding
B	0042981	biological_process	regulation of apoptotic process
B	0043232	cellular_component	intracellular non-membrane-bounded organelle
B	0043922	biological_process	negative regulation by host of viral transcription
B	0048511	biological_process	rhythmic process
B	0051726	biological_process	regulation of cell cycle
B	0061158	biological_process	3'-UTR-mediated mRNA destabilization
B	0070935	biological_process	3'-UTR-mediated mRNA stabilization
B	0071765	biological_process	nuclear inner membrane organization
B	0097157	molecular_function	pre-mRNA intronic binding
B	0140693	molecular_function	molecular condensate scaffold activity
B	1990000	biological_process	amyloid fibril formation
C	0000785	cellular_component	chromatin
C	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
C	0001933	biological_process	negative regulation of protein phosphorylation
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0003690	molecular_function	double-stranded DNA binding
C	0003723	molecular_function	RNA binding
C	0003730	molecular_function	mRNA 3'-UTR binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005726	cellular_component	perichromatin fibrils
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0006397	biological_process	mRNA processing
C	0008289	molecular_function	lipid binding
C	0008380	biological_process	RNA splicing
C	0010467	biological_process	gene expression
C	0010468	biological_process	regulation of gene expression
C	0010494	cellular_component	cytoplasmic stress granule
C	0010629	biological_process	negative regulation of gene expression
C	0016607	cellular_component	nuclear speck
C	0031647	biological_process	regulation of protein stability
C	0032024	biological_process	positive regulation of insulin secretion
C	0034976	biological_process	response to endoplasmic reticulum stress
C	0035061	cellular_component	interchromatin granule
C	0042307	biological_process	positive regulation of protein import into nucleus
C	0042752	biological_process	regulation of circadian rhythm
C	0042802	molecular_function	identical protein binding
C	0042981	biological_process	regulation of apoptotic process
C	0043232	cellular_component	intracellular non-membrane-bounded organelle
C	0043922	biological_process	negative regulation by host of viral transcription
C	0048511	biological_process	rhythmic process
C	0051726	biological_process	regulation of cell cycle
C	0061158	biological_process	3'-UTR-mediated mRNA destabilization
C	0070935	biological_process	3'-UTR-mediated mRNA stabilization
C	0071765	biological_process	nuclear inner membrane organization
C	0097157	molecular_function	pre-mRNA intronic binding
C	0140693	molecular_function	molecular condensate scaffold activity
C	1990000	biological_process	amyloid fibril formation
D	0000785	cellular_component	chromatin
D	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
D	0001933	biological_process	negative regulation of protein phosphorylation
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0003690	molecular_function	double-stranded DNA binding
D	0003723	molecular_function	RNA binding
D	0003730	molecular_function	mRNA 3'-UTR binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005726	cellular_component	perichromatin fibrils
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0006397	biological_process	mRNA processing
D	0008289	molecular_function	lipid binding
D	0008380	biological_process	RNA splicing
D	0010467	biological_process	gene expression
D	0010468	biological_process	regulation of gene expression
D	0010494	cellular_component	cytoplasmic stress granule
D	0010629	biological_process	negative regulation of gene expression
D	0016607	cellular_component	nuclear speck
D	0031647	biological_process	regulation of protein stability
D	0032024	biological_process	positive regulation of insulin secretion
D	0034976	biological_process	response to endoplasmic reticulum stress
D	0035061	cellular_component	interchromatin granule
D	0042307	biological_process	positive regulation of protein import into nucleus
D	0042752	biological_process	regulation of circadian rhythm
D	0042802	molecular_function	identical protein binding
D	0042981	biological_process	regulation of apoptotic process
D	0043232	cellular_component	intracellular non-membrane-bounded organelle
D	0043922	biological_process	negative regulation by host of viral transcription
D	0048511	biological_process	rhythmic process
D	0051726	biological_process	regulation of cell cycle
D	0061158	biological_process	3'-UTR-mediated mRNA destabilization
D	0070935	biological_process	3'-UTR-mediated mRNA stabilization
D	0071765	biological_process	nuclear inner membrane organization
D	0097157	molecular_function	pre-mRNA intronic binding
D	0140693	molecular_function	molecular condensate scaffold activity
D	1990000	biological_process	amyloid fibril formation
E	0000785	cellular_component	chromatin
E	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
E	0001933	biological_process	negative regulation of protein phosphorylation
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0003690	molecular_function	double-stranded DNA binding
E	0003723	molecular_function	RNA binding
E	0003730	molecular_function	mRNA 3'-UTR binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005726	cellular_component	perichromatin fibrils
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0006397	biological_process	mRNA processing
E	0008289	molecular_function	lipid binding
E	0008380	biological_process	RNA splicing
E	0010467	biological_process	gene expression
E	0010468	biological_process	regulation of gene expression
E	0010494	cellular_component	cytoplasmic stress granule
E	0010629	biological_process	negative regulation of gene expression
E	0016607	cellular_component	nuclear speck
E	0031647	biological_process	regulation of protein stability
E	0032024	biological_process	positive regulation of insulin secretion
E	0034976	biological_process	response to endoplasmic reticulum stress
E	0035061	cellular_component	interchromatin granule
E	0042307	biological_process	positive regulation of protein import into nucleus
E	0042752	biological_process	regulation of circadian rhythm
E	0042802	molecular_function	identical protein binding
E	0042981	biological_process	regulation of apoptotic process
E	0043232	cellular_component	intracellular non-membrane-bounded organelle
E	0043922	biological_process	negative regulation by host of viral transcription
E	0048511	biological_process	rhythmic process
E	0051726	biological_process	regulation of cell cycle
E	0061158	biological_process	3'-UTR-mediated mRNA destabilization
E	0070935	biological_process	3'-UTR-mediated mRNA stabilization
E	0071765	biological_process	nuclear inner membrane organization
E	0097157	molecular_function	pre-mRNA intronic binding
E	0140693	molecular_function	molecular condensate scaffold activity
E	1990000	biological_process	amyloid fibril formation
F	0000785	cellular_component	chromatin
F	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
F	0001933	biological_process	negative regulation of protein phosphorylation
F	0003676	molecular_function	nucleic acid binding
F	0003677	molecular_function	DNA binding
F	0003690	molecular_function	double-stranded DNA binding
F	0003723	molecular_function	RNA binding
F	0003730	molecular_function	mRNA 3'-UTR binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005726	cellular_component	perichromatin fibrils
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0006397	biological_process	mRNA processing
F	0008289	molecular_function	lipid binding
F	0008380	biological_process	RNA splicing
F	0010467	biological_process	gene expression
F	0010468	biological_process	regulation of gene expression
F	0010494	cellular_component	cytoplasmic stress granule
F	0010629	biological_process	negative regulation of gene expression
F	0016607	cellular_component	nuclear speck
F	0031647	biological_process	regulation of protein stability
F	0032024	biological_process	positive regulation of insulin secretion
F	0034976	biological_process	response to endoplasmic reticulum stress
F	0035061	cellular_component	interchromatin granule
F	0042307	biological_process	positive regulation of protein import into nucleus
F	0042752	biological_process	regulation of circadian rhythm
F	0042802	molecular_function	identical protein binding
F	0042981	biological_process	regulation of apoptotic process
F	0043232	cellular_component	intracellular non-membrane-bounded organelle
F	0043922	biological_process	negative regulation by host of viral transcription
F	0048511	biological_process	rhythmic process
F	0051726	biological_process	regulation of cell cycle
F	0061158	biological_process	3'-UTR-mediated mRNA destabilization
F	0070935	biological_process	3'-UTR-mediated mRNA stabilization
F	0071765	biological_process	nuclear inner membrane organization
F	0097157	molecular_function	pre-mRNA intronic binding
F	0140693	molecular_function	molecular condensate scaffold activity
F	1990000	biological_process	amyloid fibril formation
G	0000785	cellular_component	chromatin
G	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
G	0001933	biological_process	negative regulation of protein phosphorylation
G	0003676	molecular_function	nucleic acid binding
G	0003677	molecular_function	DNA binding
G	0003690	molecular_function	double-stranded DNA binding
G	0003723	molecular_function	RNA binding
G	0003730	molecular_function	mRNA 3'-UTR binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005726	cellular_component	perichromatin fibrils
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0006397	biological_process	mRNA processing
G	0008289	molecular_function	lipid binding
G	0008380	biological_process	RNA splicing
G	0010467	biological_process	gene expression
G	0010468	biological_process	regulation of gene expression
G	0010494	cellular_component	cytoplasmic stress granule
G	0010629	biological_process	negative regulation of gene expression
G	0016607	cellular_component	nuclear speck
G	0031647	biological_process	regulation of protein stability
G	0032024	biological_process	positive regulation of insulin secretion
G	0034976	biological_process	response to endoplasmic reticulum stress
G	0035061	cellular_component	interchromatin granule
G	0042307	biological_process	positive regulation of protein import into nucleus
G	0042752	biological_process	regulation of circadian rhythm
G	0042802	molecular_function	identical protein binding
G	0042981	biological_process	regulation of apoptotic process
G	0043232	cellular_component	intracellular non-membrane-bounded organelle
G	0043922	biological_process	negative regulation by host of viral transcription
G	0048511	biological_process	rhythmic process
G	0051726	biological_process	regulation of cell cycle
G	0061158	biological_process	3'-UTR-mediated mRNA destabilization
G	0070935	biological_process	3'-UTR-mediated mRNA stabilization
G	0071765	biological_process	nuclear inner membrane organization
G	0097157	molecular_function	pre-mRNA intronic binding
G	0140693	molecular_function	molecular condensate scaffold activity
G	1990000	biological_process	amyloid fibril formation
H	0000785	cellular_component	chromatin
H	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
H	0001933	biological_process	negative regulation of protein phosphorylation
H	0003676	molecular_function	nucleic acid binding
H	0003677	molecular_function	DNA binding
H	0003690	molecular_function	double-stranded DNA binding
H	0003723	molecular_function	RNA binding
H	0003730	molecular_function	mRNA 3'-UTR binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005726	cellular_component	perichromatin fibrils
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0006397	biological_process	mRNA processing
H	0008289	molecular_function	lipid binding
H	0008380	biological_process	RNA splicing
H	0010467	biological_process	gene expression
H	0010468	biological_process	regulation of gene expression
H	0010494	cellular_component	cytoplasmic stress granule
H	0010629	biological_process	negative regulation of gene expression
H	0016607	cellular_component	nuclear speck
H	0031647	biological_process	regulation of protein stability
H	0032024	biological_process	positive regulation of insulin secretion
H	0034976	biological_process	response to endoplasmic reticulum stress
H	0035061	cellular_component	interchromatin granule
H	0042307	biological_process	positive regulation of protein import into nucleus
H	0042752	biological_process	regulation of circadian rhythm
H	0042802	molecular_function	identical protein binding
H	0042981	biological_process	regulation of apoptotic process
H	0043232	cellular_component	intracellular non-membrane-bounded organelle
H	0043922	biological_process	negative regulation by host of viral transcription
H	0048511	biological_process	rhythmic process
H	0051726	biological_process	regulation of cell cycle
H	0061158	biological_process	3'-UTR-mediated mRNA destabilization
H	0070935	biological_process	3'-UTR-mediated mRNA stabilization
H	0071765	biological_process	nuclear inner membrane organization
H	0097157	molecular_function	pre-mRNA intronic binding
H	0140693	molecular_function	molecular condensate scaffold activity
H	1990000	biological_process	amyloid fibril formation
I	0000785	cellular_component	chromatin
I	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
I	0001933	biological_process	negative regulation of protein phosphorylation
I	0003676	molecular_function	nucleic acid binding
I	0003677	molecular_function	DNA binding
I	0003690	molecular_function	double-stranded DNA binding
I	0003723	molecular_function	RNA binding
I	0003730	molecular_function	mRNA 3'-UTR binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005726	cellular_component	perichromatin fibrils
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0006397	biological_process	mRNA processing
I	0008289	molecular_function	lipid binding
I	0008380	biological_process	RNA splicing
I	0010467	biological_process	gene expression
I	0010468	biological_process	regulation of gene expression
I	0010494	cellular_component	cytoplasmic stress granule
I	0010629	biological_process	negative regulation of gene expression
I	0016607	cellular_component	nuclear speck
I	0031647	biological_process	regulation of protein stability
I	0032024	biological_process	positive regulation of insulin secretion
I	0034976	biological_process	response to endoplasmic reticulum stress
I	0035061	cellular_component	interchromatin granule
I	0042307	biological_process	positive regulation of protein import into nucleus
I	0042752	biological_process	regulation of circadian rhythm
I	0042802	molecular_function	identical protein binding
I	0042981	biological_process	regulation of apoptotic process
I	0043232	cellular_component	intracellular non-membrane-bounded organelle
I	0043922	biological_process	negative regulation by host of viral transcription
I	0048511	biological_process	rhythmic process
I	0051726	biological_process	regulation of cell cycle
I	0061158	biological_process	3'-UTR-mediated mRNA destabilization
I	0070935	biological_process	3'-UTR-mediated mRNA stabilization
I	0071765	biological_process	nuclear inner membrane organization
I	0097157	molecular_function	pre-mRNA intronic binding
I	0140693	molecular_function	molecular condensate scaffold activity
I	1990000	biological_process	amyloid fibril formation
J	0000785	cellular_component	chromatin
J	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
J	0001933	biological_process	negative regulation of protein phosphorylation
J	0003676	molecular_function	nucleic acid binding
J	0003677	molecular_function	DNA binding
J	0003690	molecular_function	double-stranded DNA binding
J	0003723	molecular_function	RNA binding
J	0003730	molecular_function	mRNA 3'-UTR binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005726	cellular_component	perichromatin fibrils
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0006397	biological_process	mRNA processing
J	0008289	molecular_function	lipid binding
J	0008380	biological_process	RNA splicing
J	0010467	biological_process	gene expression
J	0010468	biological_process	regulation of gene expression
J	0010494	cellular_component	cytoplasmic stress granule
J	0010629	biological_process	negative regulation of gene expression
J	0016607	cellular_component	nuclear speck
J	0031647	biological_process	regulation of protein stability
J	0032024	biological_process	positive regulation of insulin secretion
J	0034976	biological_process	response to endoplasmic reticulum stress
J	0035061	cellular_component	interchromatin granule
J	0042307	biological_process	positive regulation of protein import into nucleus
J	0042752	biological_process	regulation of circadian rhythm
J	0042802	molecular_function	identical protein binding
J	0042981	biological_process	regulation of apoptotic process
J	0043232	cellular_component	intracellular non-membrane-bounded organelle
J	0043922	biological_process	negative regulation by host of viral transcription
J	0048511	biological_process	rhythmic process
J	0051726	biological_process	regulation of cell cycle
J	0061158	biological_process	3'-UTR-mediated mRNA destabilization
J	0070935	biological_process	3'-UTR-mediated mRNA stabilization
J	0071765	biological_process	nuclear inner membrane organization
J	0097157	molecular_function	pre-mRNA intronic binding
J	0140693	molecular_function	molecular condensate scaffold activity
J	1990000	biological_process	amyloid fibril formation
K	0000785	cellular_component	chromatin
K	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
K	0001933	biological_process	negative regulation of protein phosphorylation
K	0003676	molecular_function	nucleic acid binding
K	0003677	molecular_function	DNA binding
K	0003690	molecular_function	double-stranded DNA binding
K	0003723	molecular_function	RNA binding
K	0003730	molecular_function	mRNA 3'-UTR binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005726	cellular_component	perichromatin fibrils
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0006397	biological_process	mRNA processing
K	0008289	molecular_function	lipid binding
K	0008380	biological_process	RNA splicing
K	0010467	biological_process	gene expression
K	0010468	biological_process	regulation of gene expression
K	0010494	cellular_component	cytoplasmic stress granule
K	0010629	biological_process	negative regulation of gene expression
K	0016607	cellular_component	nuclear speck
K	0031647	biological_process	regulation of protein stability
K	0032024	biological_process	positive regulation of insulin secretion
K	0034976	biological_process	response to endoplasmic reticulum stress
K	0035061	cellular_component	interchromatin granule
K	0042307	biological_process	positive regulation of protein import into nucleus
K	0042752	biological_process	regulation of circadian rhythm
K	0042802	molecular_function	identical protein binding
K	0042981	biological_process	regulation of apoptotic process
K	0043232	cellular_component	intracellular non-membrane-bounded organelle
K	0043922	biological_process	negative regulation by host of viral transcription
K	0048511	biological_process	rhythmic process
K	0051726	biological_process	regulation of cell cycle
K	0061158	biological_process	3'-UTR-mediated mRNA destabilization
K	0070935	biological_process	3'-UTR-mediated mRNA stabilization
K	0071765	biological_process	nuclear inner membrane organization
K	0097157	molecular_function	pre-mRNA intronic binding
K	0140693	molecular_function	molecular condensate scaffold activity
K	1990000	biological_process	amyloid fibril formation
L	0000785	cellular_component	chromatin
L	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
L	0001933	biological_process	negative regulation of protein phosphorylation
L	0003676	molecular_function	nucleic acid binding
L	0003677	molecular_function	DNA binding
L	0003690	molecular_function	double-stranded DNA binding
L	0003723	molecular_function	RNA binding
L	0003730	molecular_function	mRNA 3'-UTR binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005726	cellular_component	perichromatin fibrils
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0006397	biological_process	mRNA processing
L	0008289	molecular_function	lipid binding
L	0008380	biological_process	RNA splicing
L	0010467	biological_process	gene expression
L	0010468	biological_process	regulation of gene expression
L	0010494	cellular_component	cytoplasmic stress granule
L	0010629	biological_process	negative regulation of gene expression
L	0016607	cellular_component	nuclear speck
L	0031647	biological_process	regulation of protein stability
L	0032024	biological_process	positive regulation of insulin secretion
L	0034976	biological_process	response to endoplasmic reticulum stress
L	0035061	cellular_component	interchromatin granule
L	0042307	biological_process	positive regulation of protein import into nucleus
L	0042752	biological_process	regulation of circadian rhythm
L	0042802	molecular_function	identical protein binding
L	0042981	biological_process	regulation of apoptotic process
L	0043232	cellular_component	intracellular non-membrane-bounded organelle
L	0043922	biological_process	negative regulation by host of viral transcription
L	0048511	biological_process	rhythmic process
L	0051726	biological_process	regulation of cell cycle
L	0061158	biological_process	3'-UTR-mediated mRNA destabilization
L	0070935	biological_process	3'-UTR-mediated mRNA stabilization
L	0071765	biological_process	nuclear inner membrane organization
L	0097157	molecular_function	pre-mRNA intronic binding
L	0140693	molecular_function	molecular condensate scaffold activity
L	1990000	biological_process	amyloid fibril formation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER183
J	SER183
K	SER183
L	SER183
B	SER183
C	SER183
D	SER183
E	SER183
F	SER183
G	SER183
H	SER183
I	SER183

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER292
J	SER292
K	SER292
L	SER292
B	SER292
C	SER292
D	SER292
E	SER292
F	SER292
G	SER292
H	SER292
I	SER292

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315

Chain	Residue	Details
A	ARG293
J	ARG293
K	ARG293
L	ARG293
B	ARG293
C	ARG293
D	ARG293
E	ARG293
F	ARG293
G	ARG293
H	ARG293
I	ARG293

---

site_id	SWS_FT_FI4
Number of Residues	60
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS79
B	LYS263
C	LYS79
C	LYS84
C	LYS95
C	LYS263
D	LYS79
D	LYS84
D	LYS95
D	LYS263
E	LYS79
E	LYS84
E	LYS95
E	LYS263
F	LYS79
F	LYS84
F	LYS95
A	LYS84
F	LYS263
G	LYS79
G	LYS84
G	LYS95
G	LYS263
H	LYS79
H	LYS84
H	LYS95
A	LYS95
H	LYS263
I	LYS79
I	LYS84
I	LYS95
I	LYS263
J	LYS79
J	LYS84
J	LYS95
A	LYS263
J	LYS263
K	LYS79
K	LYS84
K	LYS95
K	LYS263
L	LYS79
L	LYS84
L	LYS95
B	LYS79
L	LYS263
B	LYS84
B	LYS95

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364

Chain	Residue	Details
A	LYS102
J	LYS102
K	LYS102
L	LYS102
B	LYS102
C	LYS102
D	LYS102
E	LYS102
F	LYS102
G	LYS102
H	LYS102
I	LYS102

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS181
J	LYS181
K	LYS181
L	LYS181
B	LYS181
C	LYS181
D	LYS181
E	LYS181
F	LYS181
G	LYS181
H	LYS181
I	LYS181

---