4XRL

Crystal structure at room temperature of Erk2 in complex with an inhibitor

Summary for 4XRL

Entry DOI	10.2210/pdb4xrl/pdb
Descriptor	Mitogen-activated protein kinase 1, SULFATE ION, 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile, ... (4 entities in total)
Functional Keywords	serine threonine kinase inhibitor, transferase
Biological source	Rattus norvegicus (Rat)
Cellular location	Cytoplasm, cytoskeleton, spindle : P63086
Total number of polymer chains	1
Total formula weight	40319.43
Authors	Gelin, M.,Allemand, F.,Labesse, G.,Guichou, J.F. (deposition date: 2015-01-21, release date: 2016-03-23, Last modification date: 2016-03-30)
Primary citation	Gelin, M.,Delfosse, V.,Allemand, F.,Hoh, F.,Sallaz-Damaz, Y.,Pirocchi, M.,Bourguet, W.,Ferrer, J.L.,Labesse, G.,Guichou, J.F. Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71:1777-1787, 2015 Cited by PubMed: 26249358 DOI: 10.1107/S1399004715010342 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.554 Å)

Structure validation