4XRL
Crystal structure at room temperature of Erk2 in complex with an inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mitogen-activated protein kinase 1 | polymer | 345 | 40080.2 | 1 | UniProt (P63086) Pfam (PF00069) In PDB | Rattus norvegicus (Rat) | MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2 |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | A | 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | non-polymer | 143.1 | 1 | Chemie (42A) | |||
| 4 | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A: 9 - 353 (UniProt: P63086)
| PDB | External Database | Details |
|---|---|---|
| Ala 184 | Glu 184 | conflict |
| Ala 185 | Tyr 185 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40080.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 239.2 | |
| All* | Total formula weight | 40319.4 |
