PDB: 13413 件ウェブページステータス検索Chemie searchBIRD

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3PVX	Binary complex of Aflatoxin B1 Adduct modified DNA (AFB1-FAPY) with DNA Polymerase IV 分子名称: CALCIUM ION, DNA (5'-D(*AP*TP*TP*(PVX)P*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*C)-3'), ... 著者 Banerjee, S. 登録日 2010-12-07 公開日 2011-08-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.03 Å) 主引用文献 Bypass of Aflatoxin B(1) Adducts by the Sulfolobus solfataricus DNA Polymerase IV. J.Am.Chem.Soc., 133, 2011
5JCF	Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (orthorhombic form). 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Melanoma differentiation associated protein-5, ... 著者 Cusack, S, Uchikawa, E. 登録日 2016-04-15 公開日 2016-06-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016
1I3X	SOLUTION STRUCTURE OF THE A LOOP OF 23S RIBOSOMAL RNA 分子名称: 5'-R(*GP*GP*CP*UP*GP*GP*CP*UP*GP*UP*UP*CP*GP*CP*CP*AP*GP*CP*C)-3' 著者 Blanchard, S.C, Puglisi, J.D. 登録日 2001-02-17 公開日 2001-04-04 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution structure of the A loop of 23S ribosomal RNA. Proc.Natl.Acad.Sci.USA, 98, 2001
3FBN	Structure of the Mediator submodule Med7N/31 分子名称: Mediator of RNA polymerase II transcription subunit 31, Mediator of RNA polymerase II transcription subunit 7 著者 Koschubs, T, Seizl, M, Lariviere, L, Kurth, F, Baumli, S, Martin, D.E, Cramer, P. 登録日 2008-11-19 公開日 2008-12-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.007 Å) 主引用文献 Identification, structure, and functional requirement of the Mediator submodule Med7N/31 Embo J., 28, 2009
5DLG	Crystal Structure of Human DNA Polymerase Eta Inserting dGMPNPP Opposite O4-Methylhymidine 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(5DB)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Patra, A, OFlaherty, D.K, Egli, M. 登録日 2015-09-04 公開日 2016-08-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.351 Å) 主引用文献 Lesion Orientation ofO4-Alkylthymidine Influences Replication by Human DNA Polymeraseeta. Chem Sci, 7, 2016
5UI5	Crystal structure of Aquifex aeolicus sigmaN bound to promoter DNA 分子名称: DNA (30-MER), DNA (31-MER), RNA polymerase sigma factor RpoN 著者 Darst, S.A, Campbell, E.A, Rajashankar, K. 登録日 2017-01-12 公開日 2017-02-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Crystal structure of Aquifex aeolicus sigma (N) bound to promoter DNA and the structure of sigma (N)-holoenzyme. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3C2K	DNA POLYMERASE BETA with a gapped DNA substrate and DUMPNPP with Manganese in the active site 分子名称: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*DCP*DCP*DGP*DAP*DCP*DAP*DGP*DCP*DGP*DCP*DAP*DTP*DCP*DAP*DGP*DC)-3'), ... 著者 Batra, V.K, Beard, W.A, Shock, D.D, Pedersen, L.C, Wilson, S.H. 登録日 2008-01-25 公開日 2008-05-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Mol.Cell, 30, 2008
4IH5	Hepatitis C Virus polymerase NS5B (BK) with fragment-based compounds 分子名称: 4-(2-phenylhydrazinyl)-1H-pyrazolo[3,4-d]pyrimidine, RNA-directed RNA polymerase 著者 Harris, S.F, Ghate, M. 登録日 2012-12-18 公開日 2013-07-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 De novo fragment design: a medicinal chemistry approach to fragment-based lead generation. J.Med.Chem., 56, 2013
4XIU	Binary complex structure of Klenow fragment of Taq DNA polymerase I707L mutant with DNA containing TTT overhang 分子名称: DNA polymerase I, thermostable, MAGNESIUM ION, ... 著者 Wu, E.Y. 登録日 2015-01-07 公開日 2015-01-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A Conservative Isoleucine to Leucine Mutation Causes Major Rearrangements and Cold Sensitivity in KlenTaq1 DNA Polymerase. Biochemistry, 54, 2015
5MJV	Rebuild and re-refined model for Human Parechovirus 1 分子名称: CAPSID SUBUNIT VP0, CAPSID SUBUNIT VP1, CAPSID SUBUNIT VP3, ... 著者 Shakeel, S, Dykeman, E.C, White, S.J, Ora, A, Cockburn, J.J.B, Butcher, S.J, Stockley, P.G, Twarock, R. 登録日 2016-12-01 公開日 2017-01-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Genomic RNA folding mediates assembly of human parechovirus. Nat Commun, 8, 2017
4RUA	Crystal structure of Y-family DNA polymerase Dpo4 bypassing a MeFapy-dG adduct 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase IV, ... 著者 Patra, A, Banerjee, S, Stone, M.P, Egli, M. 登録日 2014-11-18 公開日 2015-08-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.07 Å) 主引用文献 Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase eta and Sulfolobus solfataricus P2 Polymerase IV. J.Am.Chem.Soc., 137, 2015
4XUS	Crystal structure of the pre-catalytic ternary complex of DNA polymerase lambda with a templating A and an incoming dTTP 分子名称: 2',3'-DIDEOXYCYTIDINE-5'-MONOPHOSPHATE, DNA (5'-D(*CP*AP*GP*TP*A)-3'), DNA (5'-D(*CP*GP*GP*CP*AP*GP*TP*AP*CP*TP*G)-3'), ... 著者 Burak, M.J, Guja, K.E, Garcia-Diaz, M. 登録日 2015-01-26 公開日 2016-02-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase lambda. Nucleic Acids Res., 43, 2015
4RU9	Crystal structure of human DNA polymerase eta inserting dCMPNPP opposite a MeFapy-dG adducted DNA template 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA polymerase eta, MAGNESIUM ION, ... 著者 Patra, A, Egli, M. 登録日 2014-11-18 公開日 2015-08-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase eta and Sulfolobus solfataricus P2 Polymerase IV. J.Am.Chem.Soc., 137, 2015
8DVU	Cryo-EM structure of RIG-I bound to the internal sites of OHSLR30 (+ATP) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Antiviral innate immune response receptor RIG-I, MAGNESIUM ION, ... 著者 Wang, W, Pyle, A.M. 登録日 2022-07-29 公開日 2022-11-16 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
5YTE	Large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with with natural dT:dATP base pair 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*AP*TP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ... 著者 Zeng, H, Mondal, M, Song, R.Y, Zhang, J, Xia, B, Gao, Y.Q, Yi, C.Q. 登録日 2017-11-17 公開日 2018-11-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry. Angew. Chem. Int. Ed. Engl., 58, 2019
7QHL	Crystal structure of Cyclin-dependent kinase 2/cyclin A in complex with 3,5,7-Substituted pyrazolo[4,3-d]pyrimidine inhibitor 24 分子名称: 1,2-ETHANEDIOL, 5-(2-amino-1-ethyl)thio-3-cyclobutyl-7-[4-(pyrazol-1-yl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidine, Cyclin-A2, ... 著者 Djukic, S, Skerlova, J, Rezacova, P. 登録日 2021-12-13 公開日 2022-07-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 3,5,7-Substituted Pyrazolo[4,3- d ]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders. J.Med.Chem., 65, 2022
5YTD	large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with the natural base pair 5fC:dGTP 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*AP*(5FC)P*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ... 著者 Zeng, H, Mondal, M, Song, R.Y, Zhang, J, Xia, B, Gao, Y.Q, Yi, C.Q. 登録日 2017-11-17 公開日 2018-11-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry. Angew. Chem. Int. Ed. Engl., 58, 2019
5YTC	Large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with the unnatural base M-fC pair with dATP in the active site 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*AP*(92F)P*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC)P*(DOC))-3'), ... 著者 Zeng, H, Mondal, M, Song, R.Y, Zhang, J, Xia, B, Yi, C.Q. 登録日 2017-11-17 公開日 2018-11-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry. Angew. Chem. Int. Ed. Engl., 58, 2019
4RUC	Crystal structure of Y-family DNA polymerase Dpo4 extending from a MeFapy-dG:dC pair 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase IV, ... 著者 Patra, A, Banerjee, S, Stone, M.P, Egli, M. 登録日 2014-11-18 公開日 2015-08-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase eta and Sulfolobus solfataricus P2 Polymerase IV. J.Am.Chem.Soc., 137, 2015
6ZV3	TFIIS N-terminal domain (TND) from human MED26 分子名称: Mediator of RNA polymerase II transcription subunit 26 著者 Veverka, V. 登録日 2020-07-23 公開日 2021-12-01 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
3CW1	Crystal Structure of Human Spliceosomal U1 snRNP 分子名称: Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, ... 著者 Pomeranz Krummel, D.A, Oubridge, C, Leung, A.K, Li, J, Nagai, K. 登録日 2008-04-21 公開日 2009-03-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (5.493 Å) 主引用文献 Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution. Nature, 458, 2009
7K96	Human DNA polymerase beta ternary complex with templating cytosine and incoming deoxyguanosine diphosphate 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYGUANOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... 著者 Varela, F.A, Freudenthal, B.D. 登録日 2020-09-28 公開日 2021-02-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Mechanism of Deoxyguanosine Diphosphate Insertion by Human DNA Polymerase beta. Biochemistry, 60, 2021
5DQG	Crystal Structure of Human DNA Polymerase Eta Inserting dAMPNPP Opposite O4-Ethylthymidine 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(5EJ)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Patra, A, OFlaherty, D.K, Egli, M. 登録日 2015-09-14 公開日 2016-08-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Lesion Orientation ofO4-Alkylthymidine Influences Replication by Human DNA Polymeraseeta. Chem Sci, 7, 2016
6HV9	S. cerevisiae CMG-Pol epsilon-DNA 分子名称: Cell division control protein 45, DNA (5'-D(*GP*CP*AP*GP*CP*CP*AP*CP*GP*CP*TP*GP*GP*CP*CP*GP*TP*TP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*AP*AP*CP*GP*GP*CP*CP*AP*GP*CP*GP*TP*GP*GP*CP*TP*GP*C)-3'), ... 著者 Abid Ali, F, Purkiss, A.G, Cheung, A, Costa, A. 登録日 2018-10-10 公開日 2018-12-12 最終更新日 2023-07-05 実験手法 ELECTRON MICROSCOPY (4.98 Å) 主引用文献 Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome. Nat Commun, 9, 2018
5DQH	Crystal Structure of Human DNA Polymerase Eta Inserting dGMPNPP Opposite O4-Ethylthymidine 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(5EJ)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Patra, A, OFlaherty, D.K, Egli, M. 登録日 2015-09-14 公開日 2016-08-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Lesion Orientation ofO4-Alkylthymidine Influences Replication by Human DNA Polymeraseeta. Chem Sci, 7, 2016

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