2GPQ
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3FAJ
| Structure of the structural protein P131 of the archaeal virus Acidianus Two-tailed virus (ATV) | 分子名称: | CHLORIDE ION, Putative uncharacterized protein | 著者 | Goulet, A, Vestergaard, G, Scheele, U, Campanacci, V, Garrett, R.A, Cambillau, C. | 登録日 | 2008-11-17 | 公開日 | 2009-11-24 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of the structural protein P131 of the archaeal virus Acidianus Two-tailed virus (ATV) To be Published
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2R0U
| Crystal Structure of Chek1 in Complex with Inhibitor 54 | 分子名称: | 6-(3-aminopropyl)-4-(3-hydroxyphenyl)-9-(1H-pyrazol-4-yl)benzo[h]isoquinolin-1(2H)-one, Serine/threonine-protein kinase Chk1 | 著者 | Yan, Y, Ikuta, M. | 登録日 | 2007-08-21 | 公開日 | 2007-10-30 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase. Bioorg.Med.Chem.Lett., 17, 2007
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4PNS
| Crystal Structure of human Tankyrase 2 in complex with INH2BP. | 分子名称: | 6-amino-5-iodo-2H-chromen-2-one, GLYCEROL, Tankyrase-2, ... | 著者 | Qiu, W, Lam, R, Romanov, V, Gordon, R, Gebremeskel, S, Vodsedalek, J, Thompson, C, Beletskaya, I, Battaile, K.P, Pai, E.F, Chirgadze, N.Y. | 登録日 | 2014-05-25 | 公開日 | 2014-10-15 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2. Acta Crystallogr.,Sect.D, 70, 2014
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3BIM
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3B66
| Crystal structure of the androgen receptor ligand binding domain in complex with SARM S-21 | 分子名称: | 4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile, Androgen receptor | 著者 | Bohl, C.E, Miller, D.D, Dalton, J.T. | 登録日 | 2007-10-27 | 公開日 | 2008-09-09 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators Bioorg.Med.Chem.Lett., 18, 2008
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4IZ5
| Structure of the complex between ERK2 phosphomimetic mutant and PEA-15 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Astrocytic phosphoprotein PEA-15, Mitogen-activated protein kinase 1, ... | 著者 | Mace, P.D, Robinson, H, Riedl, S.J. | 登録日 | 2013-01-29 | 公開日 | 2013-04-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun, 4, 2013
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3B45
| Crystal structure of GlpG at 1.9A resolution | 分子名称: | glpG, nonyl beta-D-glucopyranoside | 著者 | Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y. | 登録日 | 2007-10-23 | 公開日 | 2008-01-22 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG. J.Mol.Biol., 374, 2007
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2JGN
| DDX3 helicase domain | 分子名称: | ATP-DEPENDENT RNA HELICASE DDX3X | 著者 | Rodamilans, B, Montoya, G. | 登録日 | 2007-02-13 | 公開日 | 2008-05-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Expression, Purification, Crystallization and Preliminary X-Ray Diffraction Analysis of the Ddx3 RNA Helicase Domain. Acta Crystallogr.,Sect.F, 63, 2007
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4NJP
| Proteolysis inside the membrane is a rate-governed reaction not Driven by substrate affinity | 分子名称: | Rhomboid protease GlpG | 著者 | Dickey, S.W, Baker, R.P, Cho, S, Urban, S. | 登録日 | 2013-11-11 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity. Cell(Cambridge,Mass.), 155, 2013
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3B6Y
| Crystal Structure of the Second HIN-200 Domain of Interferon-Inducible Protein 16 | 分子名称: | Gamma-interferon-inducible protein Ifi-16, SULFATE ION | 著者 | Liao, J.C.C, Lam, R, Ravichandran, M, Duan, S, Tempel, W, Chirgadze, N.Y, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2007-10-29 | 公開日 | 2007-11-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Crystal Structure Analysis of the Second HIN Domain of IFI16. To be Published
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6B1C
| Macrophage Migration Inhibitory Factor in complex with a Naphthyridinone Inhibitor (4a) | 分子名称: | 2-[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-7-methyl-1,7-naphthyridin-8(7H)-one, Macrophage migration inhibitory factor, SULFATE ION | 著者 | Krimmer, S.G, Robertson, M.J, Jorgensen, W.L. | 登録日 | 2017-09-18 | 公開日 | 2018-01-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.163 Å) | 主引用文献 | Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor. ACS Med Chem Lett, 8, 2017
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4L02
| Crystal Structure of SphK1 with inhibitor | 分子名称: | (2R,4S)-1-[2-(4-{[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]amino}phenyl)ethyl]-2-(hydroxymethyl)piperidin-4-ol, Sphingosine kinase 1 | 著者 | Min, X, Walker, N, Wang, Z. | 登録日 | 2013-05-30 | 公開日 | 2013-07-24 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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2HVC
| The Crystal Structure of Ligand-binding Domain (LBD) of human Androgen Receptor in Complex with a selective modulator LGD2226 | 分子名称: | 6-[BIS(2,2,2-TRIFLUOROETHYL)AMINO]-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE, Androgen receptor | 著者 | Wang, F, Liu, X.-Q, Li, H, Liang, K.-N, Miner, J.N, Hong, M, Kallel, E.A, van Oeveren, A, Zhi, L, Jiang, T. | 登録日 | 2006-07-28 | 公開日 | 2007-07-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of the ligand-binding domain (LBD) of human androgen receptor in complex with a selective modulator LGD2226 ACTA CRYSTALLOGR.,SECT.F, 62, 2006
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6B2C
| Macrophage Migration Inhibitory Factor in Complex with a Naphthyridinone Inhibitor (4b) | 分子名称: | Macrophage migration inhibitory factor, SULFATE ION, {2-[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-8-oxo-1,7-naphthyridin-7(8H)-yl}acetic acid | 著者 | Krimmer, S.G, Robertson, M.J, Jorgensen, W.L. | 登録日 | 2017-09-19 | 公開日 | 2018-01-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor. ACS Med Chem Lett, 8, 2017
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3DAB
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4PUF
| Complex between the Salmonella T3SS effector SlrP and its human target thioredoxin-1 | 分子名称: | E3 ubiquitin-protein ligase SlrP, Thioredoxin | 著者 | Zouhir, S, Bernal-Bayard, J, Cordero-Alba, M, Cardenal-Munoz, E, Guimaraes, B, Lazar, N, Ramos-Morales, F, Nessler, S. | 登録日 | 2014-03-13 | 公開日 | 2014-09-17 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.296 Å) | 主引用文献 | The structure of the Slrp-Trx1 complex sheds light on the autoinhibition mechanism of the type III secretion system effectors of the NEL family. Biochem.J., 464, 2014
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4P3U
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4PNN
| Crystal Structure of human Tankyrase 2 in complex with 4HQN. | 分子名称: | Tankyrase-2, ZINC ION, quinazolin-4(1H)-one | 著者 | Qiu, W, Lam, R, Romanov, V, Gordon, R, Gebremeskel, S, Vodsedalek, J, Thompson, C, Beletskaya, I, Battaile, K.P, Pai, E.F, Chirgadze, N.Y. | 登録日 | 2014-05-24 | 公開日 | 2014-10-15 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2. Acta Crystallogr.,Sect.D, 70, 2014
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3B67
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3BEJ
| Structure of human FXR in complex with MFA-1 and co-activator peptide | 分子名称: | (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid, Bile acid receptor, Nuclear receptor coactivator 1, ... | 著者 | Soisson, S.M, Parthasarathy, G, Becker, J.W. | 登録日 | 2007-11-19 | 公開日 | 2008-03-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3DL1
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3B65
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6BG7
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3F1N
| Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains, with internally bound ethylene glycol. | 分子名称: | 1,2-ETHANEDIOL, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | 著者 | Scheuermann, T.H, Tomchick, D.R, Machius, M, Guo, Y, Bruick, R.K, Gardner, K.H. | 登録日 | 2008-10-28 | 公開日 | 2009-01-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.479 Å) | 主引用文献 | Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc.Natl.Acad.Sci.USA, 106, 2009
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