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3B67

Crystal structure of the androgen receptor ligand binding domain in complex with SARM C-23

Summary for 3B67
Entry DOI10.2210/pdb3b67/pdb
Related2axa 3B5R 3B65 3B66 3B68
DescriptorAndrogen receptor, (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide (3 entities in total)
Functional Keywordsandrogen receptor, sarm, disease mutation, dna-binding, lipid-binding, metal-binding, nucleus, polymorphism, steroid-binding, transcription, transcription regulation, triplet repeat expansion, ubl conjugation, zinc, zinc-finger
Biological sourceHomo sapiens (Human)
Cellular locationNucleus: P10275
Total number of polymer chains1
Total formula weight29520.33
Authors
Bohl, C.E.,Miller, D.D.,Dalton, J.T. (deposition date: 2007-10-27, release date: 2008-09-09, Last modification date: 2023-08-30)
Primary citationBohl, C.E.,Wu, Z.,Chen, J.,Mohler, M.L.,Yang, J.,Hwang, D.J.,Mustafa, S.,Miller, D.D.,Bell, C.E.,Dalton, J.T.
Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators
Bioorg.Med.Chem.Lett., 18:5567-5570, 2008
Cited by
PubMed: 18805694
DOI: 10.1016/j.bmcl.2008.09.002
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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