3BEJ
Structure of human FXR in complex with MFA-1 and co-activator peptide
Summary for 3BEJ
Entry DOI | 10.2210/pdb3bej/pdb |
Descriptor | Bile acid receptor, Nuclear receptor coactivator 1, YTTRIUM (III) ION, ... (5 entities in total) |
Functional Keywords | fxr, bar, nr1h4, bile acid receptor, nhr, nuclear receptor, activator, alternative splicing, dna-binding, metal-binding, nucleus, repressor, transcription, transcription regulation, zinc, zinc-finger, acyltransferase, chromosomal rearrangement, phosphoprotein, polymorphism, proto-oncogene, transferase, ubl conjugation, transcription-transferase complex, transcription regulator |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 62313.21 |
Authors | Soisson, S.M.,Parthasarathy, G.,Becker, J.W. (deposition date: 2007-11-19, release date: 2008-03-18, Last modification date: 2024-02-21) |
Primary citation | Soisson, S.M.,Parthasarathy, G.,Adams, A.D.,Sahoo, S.,Sitlani, A.,Sparrow, C.,Cui, J.,Becker, J.W. Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation. Proc.Natl.Acad.Sci.Usa, 105:5337-5342, 2008 Cited by PubMed: 18391212DOI: 10.1073/pnas.0710981105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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