1TKZ
| CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW429576 | 分子名称: | 6-CHLORO-4-(CYCLOHEXYLSULFANYL)-3-PROPYLQUINOLIN-2(1H)-ONE, PHOSPHATE ION, Pol polyprotein, ... | 著者 | Hopkins, A.L, Ren, J, Stuart, D.I, Stammers, D.K. | 登録日 | 2004-06-09 | 公開日 | 2004-12-07 | 最終更新日 | 2020-01-15 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1. J.Med.Chem., 47, 2004
|
|
5LSF
| Sacbrood honeybee virus | 分子名称: | CALCIUM ION, VP1, VP2, ... | 著者 | Plevka, P, Veselikova, M. | 登録日 | 2016-08-26 | 公開日 | 2018-08-01 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Virion structure and genome delivery mechanism of sacbrood honeybee virus. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
1TLV
| Structure of the native and inactive LicT PRD from B. subtilis | 分子名称: | Transcription antiterminator licT | 著者 | Graille, M, Zhou, C.-Z, Receveur-Brechot, V, Collinet, B, Declerck, N, van Tilbeurgh, H. | 登録日 | 2004-06-10 | 公開日 | 2005-02-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Activation of the LicT Transcriptional Antiterminator Involves a Domain Swing/Lock Mechanism Provoking Massive Structural Changes J.Biol.Chem., 280, 2005
|
|
1EYV
| THE CRYSTAL STRUCTURE OF NUSB FROM MYCOBACTERIUM TUBERCULOSIS | 分子名称: | N-UTILIZING SUBSTANCE PROTEIN B HOMOLOG, PHOSPHATE ION | 著者 | Gopal, B, Haire, L.F, Cox, R.A, Colston, M.J, Major, S, Brannigan, J.A, Smerdon, S.J, Dodson, G.G, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2000-05-09 | 公開日 | 2000-05-18 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The crystal structure of NusB from Mycobacterium tuberculosis. Nat.Struct.Biol., 7, 2000
|
|
4N7Y
| Crystal structure of 14-3-3zeta in complex with a 8-carbon-linker cyclic peptide derived from ExoS | 分子名称: | 14-3-3 protein zeta/delta, Exoenzyme S | 著者 | Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. | 登録日 | 2013-10-16 | 公開日 | 2014-02-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
|
|
1RXB
| |
2NLM
| |
1UAX
| |
6LP2
| |
1XHN
| |
4PTE
| Structure of a carvoxamide compound (15) (N-[4-(ISOQUINOLIN-7-YL)PYRIDIN-2-YL]CYCLOPROPANECARBOXAMIDE) to GSK3b | 分子名称: | Glycogen synthase kinase-3 beta, N-[4-(isoquinolin-7-yl)pyridin-2-yl]cyclopropanecarboxamide | 著者 | Lewis, H.A, Sivaprakasam, P, Kish, K, Pokross, M, Dubowchik, G.M. | 登録日 | 2014-03-10 | 公開日 | 2015-04-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.033 Å) | 主引用文献 | Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg.Med.Chem.Lett., 25, 2015
|
|
1LN0
| Structure of the Catalytic Domain of Homing Endonuclease I-TevI | 分子名称: | SULFATE ION, intron-associated endonuclease 1 | 著者 | Van Roey, P, Meehan, L, Kowalski, J.C, Belfort, M, Derbyshire, V. | 登録日 | 2002-05-02 | 公開日 | 2002-10-30 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Catalytic domain structure and hypothesis for function of GIY-YIG intron endonuclease I-TevI. Nat.Struct.Biol., 9, 2002
|
|
4PTG
| Structure of a carboxamine compound (26) (2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-METHOXYPYRIMIDINE-5-CARBOXAMIDE) to GSK3b | 分子名称: | 2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-methoxypyrimidine-5-carboxamide, Glycogen synthase kinase-3 beta | 著者 | Lewis, H.A, Sivaprakasam, P, Kish, K, Pokross, M, Dubowchik, G.M. | 登録日 | 2014-03-10 | 公開日 | 2015-04-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.361 Å) | 主引用文献 | Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg.Med.Chem.Lett., 25, 2015
|
|
4Q0O
| Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand | 分子名称: | (2E)-1-(2-hydroxyphenyl)-3-[(3R)-3-phenylpiperidin-1-yl]prop-2-en-1-one, POTASSIUM ION, Protein polybromo-1 | 著者 | Filippakopoulos, P, Picaud, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2014-04-02 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand To be Published
|
|
4N7G
| Crystal structure of 14-3-3zeta in complex with a peptide derived from ExoS | 分子名称: | 14-3-3 protein zeta/delta, Exoenzyme S, HEXAETHYLENE GLYCOL | 著者 | Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. | 登録日 | 2013-10-15 | 公開日 | 2014-02-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
|
|
4QA5
| Crystal structure of A188T/Y306F HDAC8 in complex with a tetrapeptide substrate | 分子名称: | 7-AMINO-4-METHYL-CHROMEN-2-ONE, GLYCEROL, Histone deacetylase 8, ... | 著者 | Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. | 登録日 | 2014-05-02 | 公開日 | 2014-08-06 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
|
|
1TZU
| T. maritima NusB, P212121 | 分子名称: | N utilization substance protein B homolog, SULFATE ION | 著者 | Bonin, I, Robelek, R, Benecke, H, Urlaub, H, Bacher, A, Richter, G, Wahl, M.C. | 登録日 | 2004-07-12 | 公開日 | 2004-08-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structures of the antitermination factor NusB from Thermotoga maritima and implications for RNA binding Biochem.J., 383, 2004
|
|
1TVO
| The structure of ERK2 in complex with a small molecule inhibitor | 分子名称: | 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE, Mitogen-activated protein kinase 1 | 著者 | Kinoshita, T. | 登録日 | 2004-06-30 | 公開日 | 2005-09-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex Biochem.Biophys.Res.Commun., 336, 2005
|
|
1AUZ
| SOLUTION STRUCTURE OF SPOIIAA, A PHOSPHORYLATABLE COMPONENT OF THE SYSTEM THAT REGULATES TRANSCRIPTION FACTOR SIGMA-F OF BACILLUS SUBTILIS, NMR, 24 STRUCTURES | 分子名称: | SPOIIAA | 著者 | Kovacs, H, Comfort, D, Lord, M, Campbell, I.D, Yudkin, M.D. | 登録日 | 1997-09-08 | 公開日 | 1998-07-01 | 最終更新日 | 2024-04-10 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of SpoIIAA, a phosphorylatable component of the system that regulates transcription factor sigmaF of Bacillus subtilis. Proc.Natl.Acad.Sci.USA, 95, 1998
|
|
2KJ8
| NMR structure of fragment 87-196 from the putative phage integrase IntS of E. coli: Northeast Structural Genomics Consortium target ER652A, PSI-2 | 分子名称: | Putative prophage CPS-53 integrase | 著者 | Cort, J.R, Ramelot, T.A, Wang, D, Ciccosanti, C, Janjua, H, Nair, R, Rost, B, Swapna, G, Xiao, R, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2009-05-25 | 公開日 | 2009-07-07 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structure of fragment 87-196 from the putative phage integrase IntS of E. coli To be Published
|
|
4QA6
| Crystal structure of I243N/Y306F HDAC8 in complex with a tetrapeptide substrate | 分子名称: | 7-AMINO-4-METHYL-CHROMEN-2-ONE, GLYCEROL, Histone deacetylase 8, ... | 著者 | Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. | 登録日 | 2014-05-02 | 公開日 | 2014-08-06 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.053 Å) | 主引用文献 | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
|
|
2K5S
| YmoA | 分子名称: | Modulating protein ymoA | 著者 | McFeeters, R.L, Byrd, R. | 登録日 | 2008-06-30 | 公開日 | 2008-12-09 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | The high-precision solution structure of Yersinia modulating
protein YmoA provides insight into interaction with H-NS Biochemistry, 46, 2007
|
|
4QA2
| Crystal structure of I243N HDAC8 in complex with SAHA | 分子名称: | GLYCEROL, Histone deacetylase 8, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ... | 著者 | Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. | 登録日 | 2014-05-02 | 公開日 | 2014-08-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.377 Å) | 主引用文献 | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
|
|
1FBV
| STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES | 分子名称: | SIGNAL TRANSDUCTION PROTEIN CBL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7, ... | 著者 | Zheng, N, Wang, P, Jeffrey, P.D, Pavletich, N.P. | 登録日 | 2000-07-17 | 公開日 | 2000-08-30 | 最終更新日 | 2017-10-04 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell(Cambridge,Mass.), 102, 2000
|
|
1SYL
| Crystal structure of inactive mutant dUTPase complexed with substrate dUTP | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DEOXYURIDINE-5'-TRIPHOSPHATE, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | 著者 | Barabas, O, Kovari, J, Pongracz, V, Wilmanns, M, Vertessy, B.G. | 登録日 | 2004-04-01 | 公開日 | 2004-09-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural Insights into the Catalytic Mechanism of Phosphate Ester Hydrolysis by dUTPase J.Biol.Chem., 279, 2004
|
|