4Q0O

Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand

Summary for 4Q0O

• Entry DOI: 10.2210/pdb4q0o/pdb
• Related: 4Q0N
• Descriptor: Protein polybromo-1, POTASSIUM ION, (2E)-1-(2-hydroxyphenyl)-3-[(3R)-3-phenylpiperidin-1-yl]prop-2-en-1-one, ... (4 entities in total)
• Functional Keywords: pb1, polybromo 1 isoform 1, baf180, polybromo-1d, pbrm1, brg1-associated factor 180, bromodomain, chromatin regulator, dna-binding, nucleus, transcription, transcription regulation, structural genomics consortium, sgc
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q86U86
• Total number of polymer chains: 1
• Total formula weight: 14994.48

Authors

Filippakopoulos, P.,Picaud, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-04-02, release date: 2014-05-07, Last modification date: 2023-09-20)

• Primary citation: Filippakopoulos, P.,Picaud, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC); Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand; To be Published,

Experimental method

X-RAY DIFFRACTION (1.83 Å)