PDB: 46188 件ウェブページステータス検索Chemie searchBIRD

---

4FGY	Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity 分子名称: (4R,6S,8S,12R,14R,16Z,18R,19R,20S,21S)-19,21-dihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9,11-dioxodocos-16-enoic acid, Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma 著者 Wang, R, Li, Y. 登録日 2012-06-05 公開日 2013-03-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor Gamma (PPAR-gamma) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes. Diabetologia, 56, 2013
1OSH	A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR 分子名称: Bile acid receptor, METHYL 3-{3-[(CYCLOHEXYLCARBONYL){[4'-(DIMETHYLAMINO)BIPHENYL-4-YL]METHYL}AMINO]PHENYL}ACRYLATE 著者 Downes, M, Verdecia, M.A, Roecker, A.J, Hughes, R, Hogenesch, J.B, Kast-Woelbern, H.R, Bowman, M.E, Ferrer, J.-L, Anisfeld, A.M, Edwards, P.A, Rosenfeld, J.M, Alvarez, J.G.A, Noel, J.P, Nicolaou, K.C, Evans, R.M. 登録日 2003-03-19 公開日 2003-09-23 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR Mol.Cell, 11, 2003
4FIP	Structure of the SAGA Ubp8(S144N)/Sgf11(1-72, Delta-ZnF)/Sus1/Sgf73 DUB module 分子名称: Protein SUS1, SAGA-associated factor 11, SAGA-associated factor 73, ... 著者 Samara, N.L, Ringel, A.E, Wolberger, C. 登録日 2012-06-10 公開日 2012-07-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.686 Å) 主引用文献 A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity. Structure, 20, 2012
5HLN	X-RAY CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH CHIR99021 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHIR99021, Glycogen synthase kinase-3 beta, ... 著者 White, A, Lakshminarasimhan, D, Nadupalli, A, Suto, R.K. 登録日 2016-01-15 公開日 2016-05-25 最終更新日 2016-07-27 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. Acs Chem.Biol., 11, 2016
1OVL	Crystal Structure of Nurr1 LBD 分子名称: BROMIDE ION, IODIDE ION, Orphan nuclear receptor NURR1 (MSE 414, ... 著者 Wang, Z, Liu, J, Walker, N. 登録日 2003-03-26 公開日 2003-06-03 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure and Function of Nurr1 identifies a Class of Ligand-Independent Nuclear Receptors Nature, 423, 2003
3L0E	X-ray crystal structure of a Potent Liver X Receptor Modulator 分子名称: N-(2-chloro-6-fluorobenzyl)-1-methyl-N-{[3'-(methylsulfonyl)biphenyl-4-yl]methyl}-1H-imidazole-4-sulfonamide, Nuclear receptor coactivator 2, Oxysterols receptor LXR-beta 著者 Gampe Jr, R.T. 登録日 2009-12-09 公開日 2010-04-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J.Med.Chem., 53, 2010
2O4J	Crystal Structure of Rat Vitamin D Receptor Ligand Binding Domain Complexed with VitIII 17-20Z and the NR2 Box of DRIP 205 分子名称: (1R,3R,7E,17Z)-17-(5-hydroxy-1,5-dimethylhexylidene)-2-methylene-9,10-secoestra-5,7-diene-1,3-diol, Peroxisome proliferator-activated receptor-binding protein, Vitamin D3 receptor 著者 Vanhooke, J.L, Benning, M.M, DeLuca, H.F. 登録日 2006-12-04 公開日 2007-01-30 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 New analogs of 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D(3) with conformationally restricted side chains: Evaluation of biological activity and structural determination of VDR-bound conformations. Arch.Biochem.Biophys., 460, 2007
2O4R	Crystal Structure of Rat Vitamin D Receptor Ligand Binding Domain Complexed with VitIII 17-20E and the NR2 Box of DRIP 205 分子名称: (1R,3R,7E,17E)-17-(5-hydroxy-1,5-dimethylhexylidene)-2-methylene-9,10-secoestra-5,7-diene-1,3-diol, Peroxisome proliferator-activated receptor-binding protein, Vitamin D3 receptor 著者 Vanhooke, J.L, Benning, M.M, DeLuca, H.F. 登録日 2006-12-04 公開日 2007-01-30 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 New analogs of 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D(3) with conformationally restricted side chains: Evaluation of biological activity and structural determination of VDR-bound conformations. Arch.Biochem.Biophys., 460, 2007
3WGP	Crystal Structure Analysis of Vitamin D receptor 分子名称: (1R,2R,3R,5Z,7E,14beta,17alpha)-2-(3-hydroxypropoxy)-9,10-secocholesta-5,7,10-triene-1,3,25-triol, Vitamin D3 receptor 著者 Itoh, S, Iijima, S. 登録日 2013-08-07 公開日 2014-08-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure Analysis of Vitamin D receptor to be published
3L82	X-ray Crystal structure of TRF1 and Fbx4 complex 分子名称: F-box only protein 4, Telomeric repeat-binding factor 1 著者 Zeng, Z.X, Wang, W, Yang, Y.T, Chen, Y, Yang, X.M, Diehl, J.A, Liu, X.D, Lei, M. 登録日 2009-12-29 公開日 2010-03-09 最終更新日 2013-09-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Basis of Selective Ubiquitination of TRF1 by SCF(Fbx4) Dev.Cell, 18, 2010
3WT6	A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: Active vitamin D analogues with 22R-alkyl group 分子名称: (1R,3R,7E,17beta)-17-[(2R,3R)-3-butyl-6-hydroxy-6-methylheptan-2-yl]-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor 著者 Anami, Y, Itoh, T, Yamamoto, K. 登録日 2014-04-08 公開日 2014-06-11 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A Mixed Population of Antagonist and Agonist Binding Conformers in a Single Crystal Explains Partial Agonism against Vitamin D Receptor: Active Vitamin D Analogues with 22R-Alkyl Group. J.Med.Chem., 57, 2014
3WT7	Crystal structure of VDR-LBD complexed with 22R-Butyl-2-methylidene-26,27-dimethyl-19,24-dinor-1 ,25-dihydroxyvitamin D3 分子名称: (1R,3R,7E,17beta)-17-[(2R,3R)-3-butyl-5-ethyl-5-hydroxyheptan-2-yl]-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor 著者 Anami, Y, Itoh, T, Yamamoto, K. 登録日 2014-04-08 公開日 2014-06-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A Mixed Population of Antagonist and Agonist Binding Conformers in a Single Crystal Explains Partial Agonism against Vitamin D Receptor: Active Vitamin D Analogues with 22R-Alkyl Group. J.Med.Chem., 57, 2014
2NV7	Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555 分子名称: 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME, Estrogen receptor beta, Nuclear receptor coactivator 1 著者 Mewshaw, R.E, Bowen, M.S, Harris, H.A, Xu, Z.B, Manas, E.S, Cohn, S.T, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-11-10 公開日 2007-08-21 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 ERbeta ligands. Part 5: synthesis and structure-activity relationships of a series of 4'-hydroxyphenyl-aryl-carbaldehyde oxime derivatives. Bioorg.Med.Chem.Lett., 17, 2007
2NVN	Crystal structure of a protein with a cupin-like fold and unknown function (YP_400729.1) from Synechococcus SP. PCC 7942 (Elongatus) at 2.50 A resolution 分子名称: GLYCEROL, Hypothetical protein 著者 Joint Center for Structural Genomics (JCSG) 登録日 2006-11-13 公開日 2006-12-12 最終更新日 2023-01-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of hypothetical protein (YP_400729.1) from Synechococcus SP. PCC 7942 (Elongatus) at 2.50 A resolution To be published
2PHE	Model for VP16 binding to PC4 分子名称: Alpha trans-inducing protein, TRANSCRIPTIONAL COACTIVATOR PC4 著者 Jonker, H.R.A, Wechselberger, R.W, Boelens, R, Folkers, G.E, Kaptein, R. 登録日 2007-04-11 公開日 2007-04-24 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structural Properties of the Promiscuous VP16 Activation Domain Biochemistry, 44, 2005
2PMI	Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal Transduction Pathway with Bound ATP-gamma-S 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cyclin-dependent protein kinase PHO85, PHO85 cyclin PHO80, ... 著者 Huang, K, Ferrin-O'Connell, I, Zhang, W, Leonard, G.A, O'Shea, E.K, Quiocho, F.A. 登録日 2007-04-23 公開日 2007-12-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of the Pho85-Pho80 CDK-Cyclin Complex of the Phosphate-Responsive Signal Transduction Pathway Mol.Cell, 28, 2007
2YFC	STRUCTURAL AND FUNCTIONAL INSIGHTS OF DR2231 PROTEIN, THE MAZG-LIKE NUCLEOSIDE TRIPHOSPHATE PYROPHOSPHOHYDROLASE FROM DEINOCOCCUS RADIODURANS, COMPLEXED WITH Mn and dUMP 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ... 著者 Goncalves, A.M.D, De Sanctis, D, Mcsweeney, S.M. 登録日 2011-04-05 公開日 2011-07-06 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Structural and Functional Insights Into Dr2231 Protein, the Mazg-Like Nucleoside Triphosphate Pyrophosphohydrolase from Deinococcus Radiodurans. J.Biol.Chem., 286, 2011
2BA3	NMR Structure of NikA N-terminal Fragment 分子名称: NikA 著者 Yoshida, H, Furuya, N, Lin, Y.J, Guntert, P, Komano, T, Kainosho, M. 登録日 2005-10-14 公開日 2006-10-03 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 NMR Structure of NikA N-teminal Fragment To be Published
4FHH	Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition 分子名称: N-hydroxy-2-{4-[3-(4-{[(2S)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}acetamide, Nuclear receptor coactivator 2, Vitamin D3 receptor A 著者 Fischer, J, Wang, T.T, Kaldre, D, Rochel, N, Moras, D, White, J.H, Gleason, J.L. 登録日 2012-06-06 公開日 2012-09-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Synthetically accessible non-secosteroidal hybrid molecules combining vitamin d receptor agonism and histone deacetylase inhibition. Chem.Biol., 19, 2012
3X36	Crystal structure of the human vitamin D receptor ligand binding domain complexed with 7,8-cis-1a,25-Dihydroxy-19-norvitamin D3 分子名称: (1R,3R)-5-[(2Z)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol, Vitamin D3 receptor 著者 Takimoto-Kamimura, M, Kakuda, S. 登録日 2015-01-16 公開日 2016-01-20 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Revisiting the 7,8-cis-vitamin D3 derivatives: synthesis, evaluating the biological activity, and study of the binding configuration To be Published
2YQE	Solution structure of the ARID domain of JARID1D protein 分子名称: Jumonji/ARID domain-containing protein 1D 著者 Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-03-30 公開日 2008-04-01 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the ARID domain of JARID1D protein To be Published
2YEU	Structural and functional insights of DR2231 protein, the MazG-like nucleoside triphosphate pyrophosphohydrolase from Deinococcus radiodurans, complex with Gd 分子名称: DR2231, GADOLINIUM ATOM, GLYCEROL, ... 著者 Goncalves, A.M.D, de Sanctis, D, McSweeney, S.M. 登録日 2011-03-30 公開日 2011-07-06 最終更新日 2011-09-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and Functional Insights Into Dr2231 Protein, the Mazg-Like Nucleoside Triphosphate Pyrophosphohydrolase from Deinococcus Radiodurans. J.Biol.Chem., 286, 2011
4F9M	Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator 分子名称: (9aS)-8-acetyl-N-[(2-ethyl-4-fluoronaphthalen-1-yl)methyl]-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxamide, Peroxisome proliferator-activated receptor gamma, peptide from Nuclear receptor coactivator 1 著者 Matsui, Y, Hanzawa, H. 登録日 2012-05-19 公開日 2012-08-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Synthesis and biological evaluation of novel (-)-cercosporamide derivatives as potent selective PPARg modulators Eur.J.Med.Chem., 54, 2012
2BAL	p38alpha MAP kinase bound to pyrazoloamine 分子名称: Mitogen-activated protein kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE 著者 Gerhardt, S, Pauptit, R.A, Read, J, Tucker, J, Norman, R.A, Breed, J. 登録日 2005-10-14 公開日 2005-12-06 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase. Biochemistry, 44, 2005
2BAK	p38alpha MAP kinase bound to MPAQ 分子名称: Mitogen-activated protein kinase 14, N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-YLETHOXY)QUINAZOLIN-4-YL]AMINO}-4-METHYLPHENYL)-2-MORPHOLIN-4-YLISONICOTINAMIDE 著者 Gerhardt, S, Breed, J, Pauptit, R.A, Read, J, Norman, R.A, Ward, W.H. 登録日 2005-10-14 公開日 2005-12-06 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase Biochemistry, 44, 2005

<1304130513061307130813091310131113121313131413151316131713181319>