X-ray Crystal structure of TRF1 and Fbx4 complex

Summary for 3L82

DescriptorTelomeric repeat-binding factor 1, F-box only protein 4 (3 entities in total)
Functional Keywordstrfh domain, helix, gtpase domain, adp-ribosylation, cell cycle, cell division, chromosomal protein, cytoskeleton, dna-binding, mitosis, nucleus, phosphoprotein, telomere, ubl conjugation pathway
Biological sourceHomo sapiens (human)
Cellular locationNucleus P54274
Cytoplasm (By similarity) Q9UKT5
Total number of polymer chains2
Total molecular weight50924.59
Zeng, Z.X.,Wang, W.,Yang, Y.T.,Chen, Y.,Yang, X.M.,Diehl, J.A.,Liu, X.D.,Lei, M. (deposition date: 2009-12-29, release date: 2010-03-09, Last modification date: 2013-09-25)
Primary citation
Zeng, Z.,Wang, W.,Yang, Y.,Chen, Y.,Yang, X.,Diehl, J.A.,Liu, X.,Lei, M.
Structural Basis of Selective Ubiquitination of TRF1 by SCF(Fbx4)
Dev.Cell, 18:214-225, 2010
PubMed: 20159592 (PDB entries with the same primary citation)
DOI: 10.1016/j.devcel.2010.01.007
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26813 2.6% 3.6% 4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02