1OSH

A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR

Summary for 1OSH

Entry DOI	10.2210/pdb1osh/pdb
Descriptor	Bile acid receptor, METHYL 3-{3-[(CYCLOHEXYLCARBONYL){[4'-(DIMETHYLAMINO)BIPHENYL-4-YL]METHYL}AMINO]PHENYL}ACRYLATE (3 entities in total)
Functional Keywords	nuclear receptor, ligand binding domain, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus (Probable): Q96RI1
Total number of polymer chains	1
Total formula weight	27583.72
Authors	Downes, M.,Verdecia, M.A.,Roecker, A.J.,Hughes, R.,Hogenesch, J.B.,Kast-Woelbern, H.R.,Bowman, M.E.,Ferrer, J.-L.,Anisfeld, A.M.,Edwards, P.A.,Rosenfeld, J.M.,Alvarez, J.G.A.,Noel, J.P.,Nicolaou, K.C.,Evans, R.M. (deposition date: 2003-03-19, release date: 2003-09-23, Last modification date: 2024-02-14)
Primary citation	Downes, M.,Verdecia, M.A.,Roecker, A.J.,Hughes, R.,Hogenesch, J.B.,Kast-Woelbern, H.R.,Bowman, M.E.,Ferrer, J.-L.,Anisfeld, A.M.,Edwards, P.A.,Rosenfeld, J.M.,Alvarez, J.G.,Noel, J.P.,Nicolaou, K.C.,Evans, R.M. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR Mol.Cell, 11:1079-1092, 2003 Cited by PubMed: 12718892 DOI: 10.1016/S1097-2765(03)00104-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation