1OSH
A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Bile acid receptor | polymer | 232 | 27085.1 | 1 | UniProt (Q96RI1) Pfam (PF00104) In PDB | Homo sapiens (human) | Farnesoid X-activated receptor, Farnesol receptor HRR-1, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14 |
| 2 | A | METHYL 3-{3-[(CYCLOHEXYLCARBONYL){[4'-(DIMETHYLAMINO)BIPHENYL-4-YL]METHYL}AMINO]PHENYL}ACRYLATE | non-polymer | 498.7 | 1 | Chemie (FEX) | |||
| 3 | water | water | 18.0 | 179 | Chemie (HOH) |
Sequence modifications
A: 248 - 476 (UniProt: Q96RI1)
| PDB | External Database | Details |
|---|---|---|
| Ser 245 | - | cloning artifact |
| His 246 | - | cloning artifact |
| Gly 247 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27085.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 498.7 | |
| All* | Total formula weight | 27583.7 |
