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1OSH

A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0006355biological_processregulation of DNA-templated transcription
A0032052molecular_functionbile acid binding
A0038183biological_processbile acid signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE FEX A 1
ChainResidue
AASN287
APHE340
ALEU352
AARG355
AILE356
ATYR365
AMET369
APHE370
ATYR373
AMET454
ATRP458
APHE288
APHE465
ATRP473
AHOH1142
ALEU291
ATHR292
AMET294
AALA295
AHIS298
ASER336
AILE339

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0007744|PDB:6HL1
ChainResidueDetails
APRO345
ASER375
AGLN383
AASN461

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687
ChainResidueDetails
AMET456

site_idSWS_FT_FI3
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875
ChainResidueDetails
ALEU289

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PDB entries from 2024-07-10

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