2O4R
Crystal Structure of Rat Vitamin D Receptor Ligand Binding Domain Complexed with VitIII 17-20E and the NR2 Box of DRIP 205
Summary for 2O4R
Entry DOI | 10.2210/pdb2o4r/pdb |
Related | 1RJK 1RK3 2O4J |
Descriptor | Vitamin D3 receptor, Peroxisome proliferator-activated receptor-binding protein, (1R,3R,7E,17E)-17-(5-hydroxy-1,5-dimethylhexylidene)-2-methylene-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total) |
Functional Keywords | nuclear receptor-ligand complex, hormone-growth factor receptor complex, hormone/growth factor receptor |
Biological source | Rattus norvegicus (Norway rat) More |
Cellular location | Nucleus: P13053 Q15648 |
Total number of polymer chains | 2 |
Total formula weight | 34969.25 |
Authors | Vanhooke, J.L.,Benning, M.M.,DeLuca, H.F. (deposition date: 2006-12-04, release date: 2007-01-30, Last modification date: 2023-08-30) |
Primary citation | Vanhooke, J.L.,Tadi, B.P.,Benning, M.M.,Plum, L.A.,Deluca, H.F. New analogs of 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D(3) with conformationally restricted side chains: Evaluation of biological activity and structural determination of VDR-bound conformations. Arch.Biochem.Biophys., 460:161-165, 2007 Cited by PubMed: 17227670DOI: 10.1016/j.abb.2006.11.029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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