2O4R
Crystal Structure of Rat Vitamin D Receptor Ligand Binding Domain Complexed with VitIII 17-20E and the NR2 Box of DRIP 205
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Vitamin D3 receptor | polymer | 292 | 32983.7 | 1 | UniProt (P13053) Pfam (PF00104) In PDB | Rattus norvegicus (Norway rat) | VDR, 1,25-dihydroxyvitamin D3 receptor |
| 2 | C | Peroxisome proliferator-activated receptor-binding protein | polymer | 13 | 1570.9 | 1 | UniProt (Q15648) In PDB | PBP, PPAR-binding protein, Thyroid hormone receptor-associated protein complex 220 kDa component, Trap220, Thyroid receptor-interacting protein 2, TRIP-2, p53 regulatory protein RB18A, Vitamin D receptor-interacting protein complex component DRIP205, Activator- recruited cofactor 205 kDa component, ARC205 | |
| 3 | A | (1R,3R,7E,17E)-17-(5-hydroxy-1,5-dimethylhexylidene)-2-methylene-9,10-secoestra-5,7-diene-1,3-diol | non-polymer | 414.6 | 1 | Chemie (VD5) | |||
| 4 | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
A: 116 - 423 (UniProt: P13053)
| PDB | External Database | Details |
|---|---|---|
| - | Ser 165 | deletion |
| - | Tyr 166 | deletion |
| - | Ser 167 | deletion |
| - | Pro 168 | deletion |
| - | Arg 169 | deletion |
| - | Pro 170 | deletion |
| - | Thr 171 | deletion |
| - | Leu 172 | deletion |
| - | Ser 173 | deletion |
| - | Phe 174 | deletion |
| - | Ser 175 | deletion |
| - | Gly 176 | deletion |
| - | Asn 177 | deletion |
| - | Ser 178 | deletion |
| - | Ser 179 | deletion |
| - | Ser 180 | deletion |
| - | Ser 181 | deletion |
| - | Ser 182 | deletion |
| - | Ser 183 | deletion |
| - | Asp 184 | deletion |
| - | Leu 185 | deletion |
| - | Tyr 186 | deletion |
| - | Thr 187 | deletion |
| - | Thr 188 | deletion |
| - | Ser 189 | deletion |
| - | Leu 190 | deletion |
| - | Asp 191 | deletion |
| - | Met 192 | deletion |
| - | Met 193 | deletion |
| - | Glu 194 | deletion |
| - | Pro 195 | deletion |
| - | Ser 196 | deletion |
| - | Gly 197 | deletion |
| - | Phe 198 | deletion |
| - | Ser 199 | deletion |
| - | Asn 200 | deletion |
| - | Leu 201 | deletion |
| - | Asp 202 | deletion |
| - | Leu 203 | deletion |
| - | Asn 204 | deletion |
| - | Gly 205 | deletion |
| - | Glu 206 | deletion |
| - | Asp 207 | deletion |
| - | Ser 208 | deletion |
| - | Asp 209 | deletion |
| - | Asp 210 | deletion |
| - | Pro 211 | deletion |
| Leu 424 | - | cloning artifact |
| Val 425 | - | cloning artifact |
| Pro 426 | - | cloning artifact |
| Arg 427 | - | cloning artifact |
| Gly 428 | - | cloning artifact |
| Ser 429 | - | cloning artifact |
| Met 430 | - | cloning artifact |
| Ala 431 | - | cloning artifact |
| Ile 432 | - | cloning artifact |
| Ser 433 | - | cloning artifact |
| Asp 434 | - | cloning artifact |
| Pro 435 | - | cloning artifact |
| Asn 436 | - | cloning artifact |
| Ser 437 | - | cloning artifact |
| Ser 438 | - | cloning artifact |
| Ser 439 | - | cloning artifact |
| Val 440 | - | cloning artifact |
| Asp 441 | - | cloning artifact |
| Lys 442 | - | cloning artifact |
| Leu 443 | - | cloning artifact |
| Ala 444 | - | cloning artifact |
| Ala 445 | - | cloning artifact |
| Ala 446 | - | cloning artifact |
| Leu 447 | - | cloning artifact |
| Glu 448 | - | cloning artifact |
| His 449 | - | expression tag |
| His 450 | - | expression tag |
| His 451 | - | expression tag |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34554.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 414.6 | |
| All* | Total formula weight | 34969.2 |
