3X36

Crystal structure of the human vitamin D receptor ligand binding domain complexed with 7,8-cis-1a,25-Dihydroxy-19-norvitamin D3

Summary for 3X36

• Entry DOI: 10.2210/pdb3x36/pdb
• Related: 3X31
• Descriptor: Vitamin D3 receptor, (1R,3R)-5-[(2Z)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol (3 entities in total)
• Functional Keywords: transcription, hormone receptor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P11473
• Total number of polymer chains: 1
• Total formula weight: 30209.97

Authors

Takimoto-Kamimura, M.,Kakuda, S. (deposition date: 2015-01-16, release date: 2016-01-20, Last modification date: 2024-03-20)

• Primary citation: Sawada, D.,Saito, H.,Kakuda, S.,Takimoto-Kamimura, M.,Matsumoto, Y.,Takagi, K.,Ochiai, E.,Kittaka, A.; Revisiting the 7,8-cis-vitamin D3 derivatives: synthesis, evaluating the biological activity, and study of the binding configuration; To be Published,

Experimental method

X-RAY DIFFRACTION (1.93 Å)