PDB: 3084 件ウェブページステータス検索Chemie searchBIRD

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4I6B	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain 分子名称: (7R)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one, Serine/threonine-protein kinase PLK2 著者 Pan, H. 登録日 2012-11-29 公開日 2013-11-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain. Chemmedchem, 8, 2013
4I6F	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain 分子名称: (7R)-8-cyclopentyl-7-ethyl-5-methyl-2-(2-phenyl-1H-imidazol-1-yl)-7,8-dihydropteridin-6(5H)-one, Serine/threonine-protein kinase PLK2 著者 Pan, H. 登録日 2012-11-29 公開日 2013-11-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain. Chemmedchem, 8, 2013
2L7T	Solution structure of the MFS-bound Sans CEN2 peptide 分子名称: MFS-bound Sans CEN2 peptide 著者 Pan, L, Wu, L, Wei, Z, Zhang, M. 登録日 2010-12-22 公開日 2011-03-02 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo. Science, 331, 2011
5Z7A	Crystal structure of NDP52 SKICH region 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Calcium-binding and coiled-coil domain-containing protein 2, GLYCEROL, ... 著者 Pan, L.F, Fu, T, Liu, J.P, Xie, X.Q. 登録日 2018-01-27 公開日 2019-01-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1 Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5DC2	X-RAY CRYSTAL STRUCTURE OF A ENZYMATICALLY DEGRADED BIAPENEM-ADDUCT OF L,D-TRANSPEPTIDASE 2 FROM MYCOBACTERIUM TUBERCULOSIS 分子名称: (4S)-4-methyl-2,5,7-trioxoheptanoic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... 著者 Pan, Y, Basta, L, Lamichhane, G, Bianchet, M.A. 登録日 2015-08-23 公開日 2016-10-05 最終更新日 2019-12-11 実験手法 X-RAY DIFFRACTION (2.182 Å) 主引用文献 Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem. BMC Biochem., 18, 2017
5Z9O	The crystal structure of Cyclopropane-fatty-acyl-phospholipid synthase from Lactobacillus acidophilus 分子名称: CARBONATE ION, Cyclopropane-fatty-acyl-phospholipid synthase, L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE 著者 Pan, C.L, Ma, Y.L, Wang, Q.H. 登録日 2018-02-04 公開日 2019-03-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of bacterial cyclopropane-fatty-acyl-phospholipid synthase with phospholipid. J.Biochem., 166, 2019
5Z7G	Crystal structure of TAX1BP1 SKICH region in complex with NAP1 分子名称: 5-azacytidine-induced protein 2, GLYCEROL, Tax1-binding protein 1 著者 Pan, L.F, Fu, T, Liu, J.P, Xie, X.Q, Wang, Y.L, Hu, S.C. 登録日 2018-01-28 公開日 2019-01-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1 Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5DCC	X-RAY CRYSTAL STRUCTURE OF a TEBIPENEM ADDUCT OF L,D TRANSPEPTIDASE 2 FROM MYCOBACTERIUM TUBERCULOSIS 分子名称: (4S)-4-methyl-2,5,7-trioxoheptanoic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... 著者 Pan, Y, Basta, L, Lamichhane, G, Bianchet, M.A. 登録日 2015-08-23 公開日 2016-09-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.451 Å) 主引用文献 Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem. BMC Biochem., 18, 2017
2MXP	Solution structure of NDP52 ubiquitin-binding zinc finger 分子名称: Calcium-binding and coiled-coil domain-containing protein 2, ZINC ION 著者 Pan, L, Xie, X. 登録日 2015-01-12 公開日 2015-11-11 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2 Autophagy, 11, 2015
7SN0	Crystal structure of spike protein receptor binding domain of escape mutant SARS-CoV-2 from immunocompromised patient (d146*) in complex with human receptor ACE2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Pan, J, Abraham, J, Clark, S. 登録日 2021-10-27 公開日 2021-12-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain. Science, 375, 2022
2LSR	Solution structure of harmonin N terminal domain in complex with a exon68 encoded peptide of cadherin23 分子名称: Harmonin, peptide from Cadherin-23 著者 Pan, L, Wu, L, Zhang, C, Zhang, M. 登録日 2012-05-04 公開日 2012-08-15 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia. J.Biol.Chem., 287, 2012
3CYY	The crystal structure of ZO-1 PDZ2 in complex with the Cx43 peptide 分子名称: Tight junction protein ZO-1, peptide from Gap junction alpha-1 protein 著者 Pan, L, Zhang, M. 登録日 2008-04-27 公開日 2008-09-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites Embo J., 27, 2008
5BTU	The structure of Diels-Alderase PyrI4 in the biosynthetic pathway of pyrroindomycins 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, PyrI4 著者 Pan, L, Guo, Y, Liu, J. 登録日 2015-06-03 公開日 2016-02-24 最終更新日 2016-03-30 実験手法 X-RAY DIFFRACTION (2.503 Å) 主引用文献 Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4 Cell Chem Biol, 23, 2016
5BU3	Crystal Structure of Diels-Alderase PyrI4 in complex with its product 分子名称: (4S,4aS,6aS,8R,9R,10aR,13R,14aS,18aR,18bR)-9-ethyl-4,8,19-trihydroxy-10a,12,13,18a-tetramethyl-2,3,4,4a,5,6,6a,7,8,9,10,10a,13,14,18a,18b-hexadecahydro-1H-14a,17-(metheno)benzo[b]naphtho[2,1-h]azacyclododecine-16,18(15H,17H)-dione, GLYCEROL, PyrI4 著者 Pan, L, Guo, Y, Liu, J. 登録日 2015-06-03 公開日 2016-02-24 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.897 Å) 主引用文献 Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4 Cell Chem Biol, 23, 2016
3IVH	Design and Synthesis of Potent BACE-1 Inhibitors with Cellular Activity: Structure-Activity Relationship of P1 Substituents 分子名称: Beta-secretase 1, N-[(1S,2R)-3-{[1-(3-tert-butylphenyl)cyclohexyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]acetamide 著者 Pan, H. 登録日 2009-09-01 公開日 2010-01-05 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents. Bioorg.Med.Chem.Lett., 19, 2009
3IVI	Design and Synthesis of Potent BACE-1 Inhibitors with Cellular Activity: Structure-Activity Relationship of P1 Substituents 分子名称: Beta-secretase 1, GLYCEROL, N-[(1S,2R)-3-{[(5S)-5-(3-tert-butylphenyl)-4,5,6,7-tetrahydro-1H-indazol-5-yl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]acetamide, ... 著者 Pan, H. 登録日 2009-09-01 公開日 2010-01-05 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents. Bioorg.Med.Chem.Lett., 19, 2009
3K1R	Structure of harmonin NPDZ1 in complex with the SAM-PBM of Sans 分子名称: Harmonin, Usher syndrome type-1G protein 著者 Pan, L, Yan, J, Zhang, M. 登録日 2009-09-28 公開日 2010-01-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins Proc.Natl.Acad.Sci.USA, 107, 2010
4D9L	Fab structure of anti-HIV-1 gp120 V2 mAb 697 分子名称: Heavy chain of Fab fragment of anti-HIV1 gp120 V2 mAb 697, Light chain of Fab fragment of anti-HIV1 gp120 V2 mAb 697 著者 Pan, R.M, Kong, X.P. 登録日 2012-01-11 公開日 2012-03-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.485 Å) 主引用文献 Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals. Virology, 427, 2012
5XGV	The structure of Diels-Alderase PyrE3 in the biosynthetic pathway of pyrroindomycins 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, PyrE3 著者 Pan, L, Gong, Y, Guo, Y. 登録日 2017-04-18 公開日 2018-04-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.099 Å) 主引用文献 Structural Insights into a Flavin-Dependent [4 + 2] Cyclase that Catalyzes trans-Decalin Formation in Pyrroindomycin Biosynthesis. Cell Chem Biol, 25, 2018
5YT6	Crystal structure of TAX1BP1 UBZ2 in complex with mono-ubiquitin 分子名称: 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ... 著者 Pan, L, Hu, S. 登録日 2017-11-17 公開日 2018-07-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.501 Å) 主引用文献 Mechanistic Insights into Recognitions of Ubiquitin and Myosin VI by Autophagy Receptor TAX1BP1. J. Mol. Biol., 430, 2018
5ZFL	Crystal structure of beta-lactamase PenP mutant E166Y 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase 著者 Pan, X, Zhao, Y. 登録日 2018-03-06 公開日 2019-03-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The hydrolytic water molecule of Class A beta-lactamase relies on the acyl-enzyme intermediate ES* for proper coordination and catalysis. Sci Rep, 10, 2020
5ZG6	Crystal structure of beta-lactamase PenP mutant-E166Y in complex with cephaloridine as "post-acylation" intermediate 分子名称: 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, Beta-lactamase 著者 Pan, X, Zhao, Y. 登録日 2018-03-07 公開日 2019-03-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The hydrolytic water molecule of Class A beta-lactamase relies on the acyl-enzyme intermediate ES* for proper coordination and catalysis. Sci Rep, 10, 2020
5ZFT	Crystal structure of beta-lactamase PenP mutant-E166Y in complex with cephaloridine as "pre-deacylation" intermediate 分子名称: 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, Beta-lactamase 著者 Pan, X, Zhao, Y. 登録日 2018-03-07 公開日 2019-03-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 The hydrolytic water molecule of Class A beta-lactamase relies on the acyl-enzyme intermediate ES* for proper coordination and catalysis. Sci Rep, 10, 2020
5F5N	The structure of monooxygenase KstA11 in complex with NAD and its substrate 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, MAGNESIUM ION, ... 著者 Pan, L, Gong, Y. 登録日 2015-12-04 公開日 2016-12-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.304 Å) 主引用文献 Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5F5L	The structure of monooxygenase KstA11 in the biosynthetic pathway of kosinostatin 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, Monooxygenase 著者 Pan, L, Gong, Y. 登録日 2015-12-04 公開日 2016-12-21 最終更新日 2017-03-01 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade Proc. Natl. Acad. Sci. U.S.A., 114, 2017

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