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4MUG

Crystal structure of pantothenate synthetase in complex with 2-(5-methoxy-2-(morpholinosulfonylcarbamoyl)-1H-indol-1-yl)acetic acid

Summary for 4MUG
Entry DOI10.2210/pdb4mug/pdb
Related4MQ6 4MUE 4MUF 4MUH 4MUI 4MUJ 4MUK 4MUL
DescriptorPantothenate synthetase, ETHANOL, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywordsalpha beta 3-layer(aba) sandwich rossmann fold, pantoate-ligase, atp binding, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceMycobacterium tuberculosis
Total number of polymer chains2
Total formula weight64427.74
Authors
Silvestre, H.L.,Blundell, T.L. (deposition date: 2013-09-21, release date: 2014-08-27, Last modification date: 2023-09-20)
Primary citationHung, A.W.,Silvestre, H.L.,Wen, S.,George, G.P.,Boland, J.,Blundell, T.L.,Ciulli, A.,Abell, C.
Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis.
Chemmedchem, 11:38-42, 2016
Cited by
PubMed: 26486566
DOI: 10.1002/cmdc.201500414
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.54 Å)
Structure validation

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