5ZFI
Mouse kallikrein 7 in complex with 6-benzyl-1,4-diazepan-7-one derivative
Summary for 5ZFI
Entry DOI | 10.2210/pdb5zfi/pdb |
Related | 5zfh |
Descriptor | Kallikrein-7, 2-[(3Z,6R)-6-[(2,6-dichlorophenyl)methyl]-3-(dimethylhydrazinylidene)-7-oxo-1,4-diazepan-1-yl]-N-[3-(1-methyl-1H-pyrazol-4-yl)phenyl]acetamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total) |
Functional Keywords | protease, inhibitor complex, hydrolase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 25301.94 |
Authors | Sugawara, H. (deposition date: 2018-03-06, release date: 2018-06-27, Last modification date: 2023-11-22) |
Primary citation | Murafuji, H.,Sugawara, H.,Goto, M.,Oyama, Y.,Sakai, H.,Imajo, S.,Tomoo, T.,Muto, T. Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones. Bioorg. Med. Chem., 26:3639-3653, 2018 Cited by PubMed: 29884582DOI: 10.1016/j.bmc.2018.05.044 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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