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5ZFI

Mouse kallikrein 7 in complex with 6-benzyl-1,4-diazepan-7-one derivative

Summary for 5ZFI
Entry DOI10.2210/pdb5zfi/pdb
Related5zfh
DescriptorKallikrein-7, 2-[(3Z,6R)-6-[(2,6-dichlorophenyl)methyl]-3-(dimethylhydrazinylidene)-7-oxo-1,4-diazepan-1-yl]-N-[3-(1-methyl-1H-pyrazol-4-yl)phenyl]acetamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
Functional Keywordsprotease, inhibitor complex, hydrolase
Biological sourceMus musculus (Mouse)
Total number of polymer chains1
Total formula weight25301.94
Authors
Sugawara, H. (deposition date: 2018-03-06, release date: 2018-06-27, Last modification date: 2023-11-22)
Primary citationMurafuji, H.,Sugawara, H.,Goto, M.,Oyama, Y.,Sakai, H.,Imajo, S.,Tomoo, T.,Muto, T.
Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones.
Bioorg. Med. Chem., 26:3639-3653, 2018
Cited by
PubMed: 29884582
DOI: 10.1016/j.bmc.2018.05.044
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217705

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