6GXG
Tryparedoxin from Trypanosoma brucei in complex with CFT
Summary for 6GXG
Entry DOI | 10.2210/pdb6gxg/pdb |
Descriptor | Tryparedoxin, 5-(4-fluorophenyl)-2-methyl-3~{H}-thieno[2,3-d]pyrimidin-4-one, GLYCEROL, ... (5 entities in total) |
Functional Keywords | covalent inhibitor, photoreduction, inhibitor-induced dimerization, monomer-dimer mixture, oxidoreductase |
Biological source | Trypanosoma brucei brucei More |
Total number of polymer chains | 3 |
Total formula weight | 49024.19 |
Authors | Bader, N.,Wagner, A.,Hellmich, U.,Schindelin, H. (deposition date: 2018-06-27, release date: 2019-01-16, Last modification date: 2024-01-17) |
Primary citation | Wagner, A.,Le, T.A.,Brennich, M.,Klein, P.,Bader, N.,Diehl, E.,Paszek, D.,Weickhmann, A.K.,Dirdjaja, N.,Krauth-Siegel, R.L.,Engels, B.,Opatz, T.,Schindelin, H.,Hellmich, U.A. Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes. Angew. Chem. Int. Ed. Engl., 58:3640-3644, 2019 Cited by PubMed: 30605929DOI: 10.1002/anie.201810470 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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