6GXG
Tryparedoxin from Trypanosoma brucei in complex with CFT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0030178 | biological_process | negative regulation of Wnt signaling pathway |
| A | 0031397 | biological_process | negative regulation of protein ubiquitination |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0030178 | biological_process | negative regulation of Wnt signaling pathway |
| B | 0031397 | biological_process | negative regulation of protein ubiquitination |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0030178 | biological_process | negative regulation of Wnt signaling pathway |
| C | 0031397 | biological_process | negative regulation of protein ubiquitination |
| C | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue FFN A 201 |
| Chain | Residue |
| A | TRP39 |
| B | FFN201 |
| B | HOH321 |
| A | CYS40 |
| A | TRP70 |
| A | VAL106 |
| A | GLU107 |
| A | SER108 |
| A | ILE109 |
| B | TRP39 |
| B | TRP70 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue FFN B 201 |
| Chain | Residue |
| A | TRP39 |
| A | FFN201 |
| B | TRP39 |
| B | CYS40 |
| B | TRP70 |
| B | VAL106 |
| B | GLU107 |
| B | SER108 |
| B | ILE109 |
| B | HOH356 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 202 |
| Chain | Residue |
| A | HOH319 |
| B | PRO41 |
| B | PRO42 |
| B | ARG44 |
| B | GLY45 |
| B | HOH319 |
| C | GLY45 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue FFN C 201 |
| Chain | Residue |
| A | GLU52 |
| A | LYS56 |
| A | HIS57 |
| A | PRO135 |
| A | HOH351 |
| C | TRP39 |
| C | CYS40 |
| C | PRO41 |
| C | ILE109 |
| C | HOH317 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue GOL C 202 |
| Chain | Residue |
| A | PRO42 |
| B | PRO135 |
| B | HOH301 |
| B | HOH426 |
| C | ASN73 |
| C | ASP76 |
| C | HOH301 |
| C | HOH305 |
| C | HOH315 |
| C | HOH328 |
Functional Information from PROSITE/UniProt
| site_id | PS00194 |
| Number of Residues | 19 |
| Details | THIOREDOXIN_1 Thioredoxin family active site. FLyFSasWCPPCRgFtpvL |
| Chain | Residue | Details |
| A | PHE32-LEU50 | |
| B | PHE32-LEU50 |
