5DZO
 
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5EDX
 | | Crystal structure of swine CD8aa homodimer | | 分子名称: | CD8 alpha antigen | | 著者 | Liu, Y.J, Qi, J.X, Zhang, N.Z, Xia, C. | | 登録日 | 2015-10-22 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | | 主引用文献 | The structural basis of chicken, swine and bovine CD8 alpha alpha dimers provides insight into the co-evolution with MHC I in endotherm species.
Sci Rep, 6, 2016
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5DZL
 | | Crystal structure of the protein human CEACAM1 | | 分子名称: | Carcinoembryonic antigen-related cell adhesion molecule 1 | | 著者 | Huang, Y.H, Russell, A, Gandhi, A.K, Kondo, Y, Chen, Q, Petsko, G.A, Blumberg, R.S. | | 登録日 | 2015-09-25 | | 公開日 | 2015-10-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.4006 Å) | | 主引用文献 | CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Nature, 517, 2015
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5DZN
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5E56
 | | Crystal structure of mouse CTLA-4 | | 分子名称: | Cytotoxic T-lymphocyte protein 4, SODIUM ION | | 著者 | Fedorov, A.A, Fedorov, E.V, SAMANTA, D, Bonanno, J.B, Almo, S.C. | | 登録日 | 2015-10-07 | | 公開日 | 2015-10-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.504 Å) | | 主引用文献 | Crystal structure of mouse CTLA-4
To Be Published
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5EB9
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5E5M
 | | Crystal structure of mouse CTLA-4 in complex with nanobody | | 分子名称: | CTLA-4 nanobody, Cytotoxic T-lymphocyte protein 4, GLYCEROL | | 著者 | Fedorov, A.A, Fedorov, E.V, Samanta, D, Bonanno, J.B, Almo, S.C. | | 登録日 | 2015-10-08 | | 公開日 | 2016-10-12 | | 最終更新日 | 2019-01-30 | | 実験手法 | X-RAY DIFFRACTION (2.182 Å) | | 主引用文献 | Crystal structure of mouse CTLA-4 in complex with nanobody
To Be Published
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5EBG
 | | Crystal structure of bovine CD8aa homodimer | | 分子名称: | T-cell surface glycoprotein CD8 alpha chain | | 著者 | Liu, Y, Li, X, Zhang, N, Qi, J, Xia, C. | | 登録日 | 2015-10-19 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The structural basis of chicken, swine and bovine CD8 alpha alpha dimers provides insight into the co-evolution with MHC I in endotherm species.
Sci Rep, 6, 2016
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5ELI
 | | Triggering receptor expressed on myeloid cells 2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Triggering receptor expressed on myeloid cells 2 | | 著者 | Brett, T.J, Kober, D.L. | | 登録日 | 2015-11-04 | | 公開日 | 2016-12-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.0977 Å) | | 主引用文献 | Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.
Elife, 5, 2016
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5D4K
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5C9K
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5C6W
 | | anti-CXCL13 scFv - E10 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Tu, C, Bard, J, Mosyak, L. | | 登録日 | 2015-06-23 | | 公開日 | 2015-11-04 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Optimization of a scFv-based biotherapeutic by CDR side-chain clash repair
To Be Published
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5C2B
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5F7F
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5F1S
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5F71
 | | Human T-cell immunoglobulin and mucin domain protein 3 (hTIM-3) | | 分子名称: | Hepatitis A virus cellular receptor 2, SODIUM ION | | 著者 | Gao, G.F, Lu, G, Wang, H, Qi, J. | | 登録日 | 2015-12-07 | | 公開日 | 2016-02-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.404 Å) | | 主引用文献 | Crystal structures of human TIM members: Ebolavirus entry-enhancing receptors
Chin.Sci.Bull., 60, 2015
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5F70
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7VUX
 | | Complex structure of PD1 and 609A-Fab | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Huang, H, Zhu, Z, Zhao, J, Jiang, L, Yang, H, Deng, L, Meng, X, Ding, J, Yang, S, Zhao, L, Xu, W, Wang, X. | | 登録日 | 2021-11-04 | | 公開日 | 2021-11-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | A strategy for the efficient construction of anti-PD1-based bispecific antibodies with desired IgG-like properties.
Mabs, 14, 2022
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7VUN
 | | Design, modification, evaluation and cocrystal studies of novel phthalimides regulating PD-1/PD-L1 interaction | | 分子名称: | (2~{S},3~{S})-2-[[6-[(3-cyanophenyl)methoxy]-2-(2-methyl-3-phenyl-phenyl)-1,3-bis(oxidanylidene)isoindol-5-yl]methylamino]-3-oxidanyl-butanoic acid, Programmed cell death 1 ligand 1 | | 著者 | Cheng, Y, Sun, C.L, Chen, M.R, Yang, P, Xiao, Y.B. | | 登録日 | 2021-11-03 | | 公開日 | 2022-09-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | | 主引用文献 | Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents.
Acta Pharm Sin B, 12, 2022
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7WSL
 | | PD-1 in complex with Dostarlimab | | 分子名称: | Programmed cell death protein 1, heavy chain, light chain | | 著者 | Heo, Y.S. | | 登録日 | 2022-01-30 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.534 Å) | | 主引用文献 | Molecular basis of PD-1 blockade by dostarlimab, the FDA-approved antibody for cancer immunotherapy.
Biochem.Biophys.Res.Commun., 599, 2022
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7WVM
 | | The complex structure of PD-1 and cemiplimab | | 分子名称: | Heavy Chain of Cemiplimab, Light Chain of Cemiplimab, Programmed cell death protein 1 | | 著者 | Lu, D, Xu, Z.P, Liu, K.F, Tan, S.G, Gao, G.F, Chai, Y. | | 登録日 | 2022-02-10 | | 公開日 | 2022-04-20 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | PD-1 N58-Glycosylation-Dependent Binding of Monoclonal Antibody Cemiplimab for Immune Checkpoint Therapy.
Front Immunol, 13, 2022
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7VYT
 | | Crystal structure of human TIGIT(23-129) in complex with the scFv fragment of anti-TIGIT antibody MG1131 | | 分子名称: | CITRATE ANION, MG1131 heavy chain variable region, MG1131 light chain variable region, ... | | 著者 | Jeong, B.-S, Nam, H, Kim, M, Oh, B.-H. | | 登録日 | 2021-11-15 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Structural and functional characterization of a monoclonal antibody blocking TIGIT.
Mabs, 14, 2022
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7YDS
 | | The structure of the bispecific antibody targeted PD-L1 and 4-1BB | | 分子名称: | Anti-PDL1-VH-CH1, Anti-PDL1-VL-CL, Programmed cell death 1 ligand 1 | | 著者 | Gao, Y, Zhu, M, Liu, W.T, Cheng, L.S, Zhu, Z.L, Niu, L.W. | | 登録日 | 2022-07-04 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A bispecific antibody targeted PD-L1 and 4-1BB induces a potent antitumor immune activity in colorectal cancer without systemic toxicity
To Be Published
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4OB5
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4NOB
 | | Crystal structure of the 1st Ig domain from mouse Polymeric Immunoglobulin receptor [PSI-NYSGRC-006220] | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... | | 著者 | Kumar, P.R, Banu, R, Bhosle, R, Calarese, D.A, Celikgil, A, Chamala, S, Chan, M.K, Chowdhury, S, Fiser, A, Garforth, S.J, Glenn, A.S, Hillerich, B, Khafizov, K, Attonito, J, Love, J.D, Patel, H, Patel, R, Seidel, R.D, Smith, B, Stead, M, Casadevall, A, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | | 登録日 | 2013-11-19 | | 公開日 | 2013-12-04 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Crystal structure of the 1st Ig domain from mouse Polymeric Immunoglobulin receptor
to be published
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