2L8M
| Reduced and CO-bound cytochrome P450cam (CYP101A1) | 分子名称: | CAMPHOR, CARBON MONOXIDE, CHLORIDE ION, ... | 著者 | Pochapsky, T.C, Pochapsky, S.S, Dang, M, Asciutto, E, Madura, J. | 登録日 | 2011-01-19 | 公開日 | 2011-02-16 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Experimentally Restrained Molecular Dynamics Simulations for Characterizing the Open States of Cytochrome P450(cam). Biochemistry, 50, 2011
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2LQD
| Reduced and CO-bound cytochrome P450cam (CYP101A1) | 分子名称: | CARBON MONOXIDE, Camphor 5-monooxygenase, POTASSIUM ION, ... | 著者 | Pochapsky, T.C, Pochapsky, S.S, Asciutto, E, Madura, J, Young, M.J. | 登録日 | 2012-03-02 | 公開日 | 2012-05-09 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structural Ensembles of Substrate-Free Cytochrome P450(cam). Biochemistry, 51, 2012
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2JJP
| Structure of cytochrome P450 EryK in complex with inhibitor ketoconazole (KC) | 分子名称: | 1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE, CYTOCHROME P450 113A1, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Savino, C, Sciara, G, Miele, A.E, Kendrew, S.G, Vallone, B. | 登録日 | 2008-04-15 | 公開日 | 2009-07-14 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Azole Drugs Trap Cytochrome P450 Eryk in Alternative Conformational States. Biochemistry, 49, 2010
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2JJO
| Structure of cytochrome P450 EryK in complex with its natural substrate erD | 分子名称: | CYTOCHROME P450 113A1, Erythromycin D, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Savino, C, Sciara, G, Miele, A.E, Kendrew, S.G, Vallone, B. | 登録日 | 2008-04-15 | 公開日 | 2009-07-14 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Investigating the Structural Plasticity of a Cytochrome P450: Three-Dimensional Structures of P450 Eryk and Binding to its Physiological Substrate. J.Biol.Chem., 284, 2009
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8SO2
| Human CYP3A4 bound to a substrate | 分子名称: | CAFFEINE, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sevrioukova, I.F. | 登録日 | 2023-04-28 | 公開日 | 2023-08-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding. J.Biol.Chem., 299, 2023
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8SPD
| Cytochrome P450 (CYP) 3A4 crystallized with clotrimazole | 分子名称: | 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Hsu, M.H, Johnson, E.F. | 登録日 | 2023-05-02 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Differential Effects of Clotrimazole on X-Ray Crystal Structures of Human Cytochromes P450 3A5 and 3A4. Drug Metab.Dispos., 51, 2023
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8TAW
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8TAY
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8SPC
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2NNI
| CYP2C8dH complexed with montelukast | 分子名称: | Cytochrome P450 2C8, MONTELUKAST, PALMITIC ACID, ... | 著者 | Schoch, G.A, Yano, J.K, Stout, C.D, Johnson, E.F. | 登録日 | 2006-10-24 | 公開日 | 2007-10-23 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J.Biol.Chem., 283, 2008
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8SS0
| Human sterol 14 alpha-demethylase (CYP51) in complex with the reaction intermediate 14 alpha-aldehyde dihydrolanosterol | 分子名称: | 3beta-hydroxy-10alpha,13alpha-lanosta-8,24-dien-30-al, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Hargrove, T.Y, Wawrzak, Z, Guengerich, F.P, Lepesheva, G.I. | 登録日 | 2023-05-08 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14 alpha-Demethylation. Angew.Chem.Int.Ed.Engl., 63, 2024
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8SWL
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2NNH
| CYP2C8dH complexed with 2 molecules of 9-cis retinoic acid | 分子名称: | (9cis)-retinoic acid, Cytochrome P450 2C8, PALMITIC ACID, ... | 著者 | Schoch, G.A, Yano, J.K, Stout, C.D, Johnson, E.F. | 登録日 | 2006-10-24 | 公開日 | 2007-10-23 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J.Biol.Chem., 283, 2008
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2NNJ
| CYP2C8dH complexed with felodipine | 分子名称: | Cytochrome P450 2C8, FELODIPINE, PALMITIC ACID, ... | 著者 | Schoch, G.A, Yano, J.K, Stout, C.D, Johnson, E.F. | 登録日 | 2006-10-24 | 公開日 | 2007-10-23 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J.Biol.Chem., 283, 2008
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2NNB
| The Q403K mutant heme domain of flavocytochrome P450 BM3 | 分子名称: | Bifunctional P-450:NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Clark, J.P, Anderson, J.L.R, Miles, C.S, Mowat, C.G, Reid, G.A, Chapman, S.K. | 登録日 | 2006-10-24 | 公開日 | 2007-09-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Q403K mutant heme domain of flavocytochrome P450 BM3 To be published
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8TWU
| Crystal structure of Cytochrome P450 AspB bound to N1-methylated cyclo-L-Trp-L-Pro | 分子名称: | (3S,5S,8aS)-3-[(1-methyl-1H-indol-3-yl)methyl]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, Cytochrome P450 AspB, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Gering, H.E, Li, X, Tang, H, Swartz, P.D, Chang, W.-C, Makris, T.M. | 登録日 | 2023-08-21 | 公開日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization. J.Am.Chem.Soc., 145, 2023
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8TNK
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8TDQ
| SFX-XFEL structure of CYP121 cocrystallized with substrate cYY | 分子名称: | (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Nguyen, R.C, Dasgupta, M, Bhowmick, A, Kern, J.F, Liu, A. | 登録日 | 2023-07-04 | 公開日 | 2023-11-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | In Situ Structural Observation of a Substrate- and Peroxide-Bound High-Spin Ferric-Hydroperoxo Intermediate in the P450 Enzyme CYP121. J.Am.Chem.Soc., 145, 2023
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8TDP
| Time-resolved SFX-XFEL crystal structure of CYP121 bound with cYY reacted with peracetic acid for 200 milliseconds | 分子名称: | (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, HYDROGEN PEROXIDE, Mycocyclosin synthase, ... | 著者 | Nguyen, R.C, Dasgupta, M, Bhowmick, A, Kern, J.F, Liu, A. | 登録日 | 2023-07-04 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | In Situ Structural Observation of a Substrate- and Peroxide-Bound High-Spin Ferric-Hydroperoxo Intermediate in the P450 Enzyme CYP121. J.Am.Chem.Soc., 145, 2023
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8U3N
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8U2M
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2NZ5
| Structure and Function Studies of Cytochrome P450 158A1 from Streptomyces coelicolor A3(2) | 分子名称: | Cytochrome P450 CYP158A1, PROTOPORPHYRIN IX CONTAINING FE, naphthalene-1,2,4,5,7-pentol | 著者 | Zhao, B, Lamb, D.C, Kelly, S.L, Waterman, M.R. | 登録日 | 2006-11-22 | 公開日 | 2007-07-03 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Different binding modes of two flaviolin substrate molecules in cytochrome P450 158A1 (CYP158A1) compared to CYP158A2. Biochemistry, 46, 2007
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2NZA
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8UKZ
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8VFR
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