2NNH
CYP2C8dH complexed with 2 molecules of 9-cis retinoic acid
Summary for 2NNH
| Entry DOI | 10.2210/pdb2nnh/pdb |
| Related | 2NNI 2NNJ |
| Descriptor | Cytochrome P450 2C8, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total) |
| Functional Keywords | cyp2c8; human p450 2c8; monooxygenases; substrate complex; palmitic acid; 9-cis retinoic acid; panretin, oxidoreductase, electron transport |
| Biological source | Homo sapiens (human) |
| Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P10632 |
| Total number of polymer chains | 2 |
| Total formula weight | 111248.00 |
| Authors | Schoch, G.A.,Yano, J.K.,Stout, C.D.,Johnson, E.F. (deposition date: 2006-10-24, release date: 2007-10-23, Last modification date: 2023-08-30) |
| Primary citation | Schoch, G.A.,Yano, J.K.,Sansen, S.,Dansette, P.M.,Stout, C.D.,Johnson, E.F. Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J.Biol.Chem., 283:17227-17237, 2008 Cited by PubMed: 18413310DOI: 10.1074/jbc.M802180200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report
