2NNH

CYP2C8dH complexed with 2 molecules of 9-cis retinoic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cytochrome P450 2C8	polymer	476	54054.2	2	UniProt (P10632) Pfam (PF00067)	Homo sapiens (human)	CYPIIC8; P450 form 1; P450 MP-12/MP-20; P450 IIC2; S-mephenytoin 4-hydroxylase
2	C, H (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	D, I (A, B)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	2	Chemie (HEM)
4	E, F, J, K (A, B)	(9cis)-retinoic acid	non-polymer		300.4	4	Chemie (9CR)
5	G, L (A, B)	PALMITIC ACID	non-polymer		256.4	2	Chemie (PLM)
6	M, N (A, B)	water	water		18.0	88	Chemie (HOH)

Sequence modifications

A, B: 28 - 490 (UniProt: P10632)

PDB	External Database	Details
Met 19	-	expression tag
Ala 20	-	expression tag
Lys 21	-	expression tag
Lys 22	-	expression tag
Thr 23	-	expression tag
Ser 24	-	expression tag
Ser 25	-	expression tag
Lys 26	-	expression tag
Gly 27	-	expression tag
His 491	-	expression tag
His 492	-	expression tag
His 493	-	expression tag
His 494	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	108108.3
Non-Polymers*	Number of molecules	10
	Total formula weight	3139.7
All*	Total formula weight	111248.0

*Water molecules are not included.