8SS0

Human sterol 14 alpha-demethylase (CYP51) in complex with the reaction intermediate 14 alpha-aldehyde dihydrolanosterol

Summary for 8SS0

Entry DOI	10.2210/pdb8ss0/pdb
Descriptor	Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 3beta-hydroxy-10alpha,13alpha-lanosta-8,24-dien-30-al, ... (4 entities in total)
Functional Keywords	monooxygenase, cytochrome p450, cyp51, endoplasmic reticulum, sterol biosynthesis, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	106832.60
Authors	Hargrove, T.Y.,Wawrzak, Z.,Guengerich, F.P.,Lepesheva, G.I. (deposition date: 2023-05-08, release date: 2024-01-17, Last modification date: 2024-03-06)
Primary citation	McCarty, K.D.,Tateishi, Y.,Hargrove, T.Y.,Lepesheva, G.I.,Guengerich, F.P. Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14 alpha-Demethylation. Angew.Chem.Int.Ed.Engl., 63:e202317711-e202317711, 2024 Cited by PubMed: 38206808 DOI: 10.1002/anie.202317711 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation