8SS0
Human sterol 14 alpha-demethylase (CYP51) in complex with the reaction intermediate 14 alpha-aldehyde dihydrolanosterol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Lanosterol 14-alpha demethylase | polymer | 458 | 52359.1 | 2 | UniProt (Q16850) Pfam (PF00067) In PDB | Homo sapiens (human) | LDM,CYPLI,Cytochrome P450 51A1,CYP51A1,Cytochrome P450-14DM,Cytochrome P45014DM,Cytochrome P450LI,Sterol 14-alpha demethylase |
2 | A, B | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
3 | A, B | 3beta-hydroxy-10alpha,13alpha-lanosta-8,24-dien-30-al | non-polymer | 440.7 | 2 | Chemie (WQR) | |||
4 | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A, B: 61 - 503 (UniProt: Q16850)
PDB | External Database | Details |
---|---|---|
Met 50 | - | expression tag |
Ala 51 | - | expression tag |
Lys 52 | - | expression tag |
Lys 53 | - | expression tag |
Thr 54 | - | expression tag |
Ser 55 | - | expression tag |
Ser 56 | - | expression tag |
Lys 57 | - | expression tag |
Gly 58 | - | expression tag |
Lys 59 | - | expression tag |
Leu 60 | - | expression tag |
Ala 231 | Asp 237 | engineered mutation |
Ala 314 | His 320 | engineered mutation |
His 504 | - | expression tag |
His 505 | - | expression tag |
His 506 | - | expression tag |
His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 104718.2 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 2114.4 | |
All* | Total formula weight | 106832.6 |