2NNI

CYP2C8dH complexed with montelukast

Summary for 2NNI

• Entry DOI: 10.2210/pdb2nni/pdb
• Related: 2NNH 2NNJ
• Descriptor: Cytochrome P450 2C8, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
• Functional Keywords: cyp2c8; human p450 2c8; monooxygenases; montelukast; singulair; inhibitor complex; palmitic aci, oxidoreductase, electron transport
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein: P10632
• Total number of polymer chains: 1
• Total formula weight: 55609.31

Authors

Schoch, G.A.,Yano, J.K.,Stout, C.D.,Johnson, E.F. (deposition date: 2006-10-24, release date: 2007-10-23, Last modification date: 2023-08-30)

• Primary citation: Schoch, G.A.,Yano, J.K.,Sansen, S.,Dansette, P.M.,Stout, C.D.,Johnson, E.F.; Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.; J.Biol.Chem., 283:17227-17237, 2008; PubMed: 18413310; DOI: 10.1074/jbc.M802180200

Experimental method

X-RAY DIFFRACTION (2.8 Å)