PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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6YQM	Human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with dGMP and refined to 1.02 A 分子名称: 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, Histidine triad nucleotide-binding protein 1 著者 Dolot, R.D, Seda, A, Nawrot, B.C. 登録日 2020-04-17 公開日 2020-04-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.02 Å) 主引用文献 Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A. Biochim Biophys Acta Gen Subj, 1865, 2021
3S1A	Crystal structure of the phosphorylation-site double mutant S431E/T432E of the KaiC circadian clock protein 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase kaiC, MAGNESIUM ION 著者 Pattanayek, R, Williams, D.W, Rossi, G, Weigand, S, Mori, T, Johnson, C.H, Stewart, P.L, Egli, M. 登録日 2011-05-14 公開日 2011-09-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Combined SAXS/EM Based Models of the S. elongatus Post-Translational Circadian Oscillator and its Interactions with the Output His-Kinase SasA. Plos One, 6, 2011
3NOW	UNC-45 from Drosophila melanogaster 分子名称: UNC-45 protein, SD10334p 著者 Lee, C.F, Hauenstein, A.V, Fleming, J.K, Gasper, W.C, Engelke, V, Banumathi, S, Bernstein, S.I, Huxford, T. 登録日 2010-06-25 公開日 2011-03-16 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.992 Å) 主引用文献 X-ray Crystal Structure of the UCS Domain-Containing UNC-45 Myosin Chaperone from Drosophila melanogaster. Structure, 19, 2011
5UYR	Crystal structure of the dark-adapted full-length bacteriophytochrome XccBphP mutant D199A from Xanthomonas campestris 分子名称: BILIVERDINE IX ALPHA, Bacteriophytochrome 著者 Otero, L.H, Klinke, S, Goldbaum, F.A, Bonomi, H.R. 登録日 2017-02-24 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Pr-favoured variants of the bacteriophytochrome from the plant pathogen Xanthomonas campestris hint on light regulation of virulence-associated mechanisms. Febs J., 288, 2021
5YJB	LSD1-CoREST in complex with 4-[5-(piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile 分子名称: 4-[2-(4-methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]benzenecarbonitrile, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Niwa, H, Sato, S, Hashimoto, T, Matsuno, K, Umehara, T. 登録日 2017-10-10 公開日 2018-07-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.96 Å) 主引用文献 Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile. Molecules, 23, 2018
5Y8V	Crystal structure of GAS41 分子名称: MAGNESIUM ION, YEATS domain-containing protein 4 著者 Wang, Y, Hao, Q. 登録日 2017-08-21 公開日 2018-04-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6PPF	Bacterial 45SRbgA ribosomal particle class B 分子名称: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... 著者 Ortega, J, Seffouh, A, Jain, N, Jahagirdar, D, Basu, K, Razi, A, Ni, X, Guarne, A, Britton, R.A. 登録日 2019-07-06 公開日 2019-09-18 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural consequences of the interaction of RbgA with a 50S ribosomal subunit assembly intermediate. Nucleic Acids Res., 47, 2019
3HNE	Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
4YOT	Crystal structure of a trimeric exonuclease PhoExo I from Pyrococcus horikoshii OT3 at 2.15A resolution 分子名称: 3-5 exonuclease PhoExo I, MAGNESIUM ION 著者 Miyazono, K, Tsutsumi, K, Tanokura, M. 登録日 2015-03-12 公開日 2015-07-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural basis for substrate recognition and processive cleavage mechanisms of the trimeric exonuclease PhoExo I Nucleic Acids Res., 43, 2015
8R1L	Structure of avian H5N1 influenza A polymerase in complex with human ANP32B. 分子名称: Acidic leucine-rich nuclear phosphoprotein 32 family member B, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Carrique, L, Staller, E, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. 登録日 2023-11-02 公開日 2024-05-08 最終更新日 2024-07-31 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation. Nat Commun, 15, 2024
6XEZ	Structure of SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... 著者 Chen, J, Malone, B, Llewellyn, E.C, Campbell, E.A, Darst, S.A. 登録日 2020-06-14 公開日 2020-07-29 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. Cell, 182, 2020
5Y0F	Crystal structure of human FABP4 complexed with ligand 2-fluoro-5-((4-methoxynaphthalene)-1-sulfonamido) benzoic acid 分子名称: 2-fluoranyl-5-[(4-methoxynaphthalen-1-yl)sulfonylamino]benzoic acid, Fatty acid-binding protein, adipocyte 著者 Su, H.X, Liu, Q.F, Xu, Y.C. 登録日 2017-07-17 公開日 2018-06-06 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4 Eur J Med Chem, 154, 2018
6YIJ	Crystal structure of the CREBBP bromodomain in complex with a benzo-diazepine ligand 分子名称: (4~{R})-6-[(~{E})-5-(7-methoxy-3,4-dihydro-2~{H}-quinolin-1-yl)pent-1-enyl]-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one, CREBBP 著者 Picaud, S, Brand, M, Tobias, K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Conway, S, Filippakopoulos, P. 登録日 2020-04-01 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the CREBBP bromodomain in complex with a benzo-diazepine ligand To Be Published
6YIL	Crystal structure of the CREBBP bromodomain in complex with a tetrahydroquinoxaline ligand 分子名称: (3~{R})-~{N}-[3-(3,4-dihydro-2~{H}-quinolin-1-yl)-2,2-bis(fluoranyl)propyl]-3-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-quinoxaline-5-carboxamide, CREBBP 著者 Picaud, S, Brand, M, Tobias, K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Conway, S, Filippakopoulos, P. 登録日 2020-04-01 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.22 Å) 主引用文献 Crystal structure of the CREBBP bromodomain in complex with a tetrahydroquinoxaline ligand To Be Published
2M84	Structure of 2'F-RNA/2'F-ANA chimeric duplex 分子名称: 2'F-RNA/2'F-ANA CHIMERIC DUPLEX 著者 Martin-Pintado, N, Deleavey, G, Portella, G, Campos, R, Orozco, M, Damha, M, Gonzalez, C. 登録日 2013-05-07 公開日 2013-11-27 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Backbone FCHO Hydrogen Bonds in 2'F-Substituted Nucleic Acids. Angew.Chem.Int.Ed.Engl., 52, 2013
6Q0K	Structure of a MAPK pathway complex 分子名称: 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf 著者 Park, E, Rawson, S, Jeon, H, Eck, M.J. 登録日 2019-08-01 公開日 2019-10-09 最終更新日 2020-04-22 実験手法 ELECTRON MICROSCOPY (6.8 Å) 主引用文献 Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature, 575, 2019
3SZ1	Human PPAR gamma ligand binding domain in complex with luteolin and myristic acid 分子名称: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, MYRISTIC ACID, Peroxisome proliferator-activated receptor gamma, ... 著者 Puhl, A.C, Bernardes, A, Polikarpov, I. 登録日 2011-07-18 公開日 2012-03-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mode of peroxisome proliferator-activated receptor gamma activation by luteolin. Mol.Pharmacol., 81, 2012
5Y12	Crystal structure of human FABP4 complexed with ligand 5-((4-methoxynaphthalene)-1-sulfonamido)pentanoic acid 分子名称: 5-[(4-methoxynaphthalen-1-yl)sulfonylamino]pentanoic acid, Fatty acid-binding protein, adipocyte 著者 Su, H.X, Liu, Q.F, Xu, Y.C. 登録日 2017-07-19 公開日 2018-06-06 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4 Eur J Med Chem, 154, 2018
6Z3M	Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) and Neogenin 1 (NEO1). 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Growth/differentiation factor 5, Neogenin, ... 著者 Malinauskas, T, Peer, T.V, Bishop, B, Muller, T.D, Siebold, C. 登録日 2020-05-21 公開日 2020-07-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (5.501 Å) 主引用文献 Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex. Proc.Natl.Acad.Sci.USA, 117, 2020
5Y1Z	Crystal structure of ZMYND8 PHD-BROMO-PWWP tandem in complex with Drebrin ADF-H domain 分子名称: Drebrin, GLYCEROL, Protein kinase C-binding protein 1, ... 著者 Yao, N, Li, J, Liu, H, Wan, J, Liu, W, Zhang, M. 登録日 2017-07-22 公開日 2017-10-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.676 Å) 主引用文献 The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin Structure, 25, 2017
7VW5	Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold 分子名称: MAGNESIUM ION, RNA-directed RNA polymerase nsP4 著者 Tan, Y.B, Luo, D. 登録日 2021-11-09 公開日 2022-02-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold. Nucleic Acids Res., 50, 2022
7VB4	A crystal structure of alphavirus nonstructural protein 4 (nsP4) reveals an intrinsically dynamic RNA-dependent RNA polymerase 分子名称: GLYCEROL, MAGNESIUM ION, RNA-directed RNA polymerase nsP4 著者 Tan, Y.B, Luo, D. 登録日 2021-08-30 公開日 2022-02-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold. Nucleic Acids Res., 50, 2022
8RC6	Cryo-EM structure of hexameric BTB domain of Drosophila CG6765 protein 分子名称: BTB domain of CG6765 protein 著者 Bonchuk, A.N, Naschberger, A, Baradaran, R. 登録日 2023-12-06 公開日 2024-09-11 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 The Arthropoda-specific Tramtrack group BTB protein domains use previously unknown interface to form hexamers. Elife, 13, 2024
3HNC	Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP 分子名称: MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, SULFATE ION, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
8TX9	Nan Regulatory Protein (core isomerase domain) from Streptococcus pneumoniae 分子名称: 2-acetamido-2-deoxy-6-O-phosphono-alpha-D-mannopyranose, MurR/RpiR family transcriptional regulator, SODIUM ION 著者 Wood, D.M, Horne, C.R, Panjikar, S, Dobson, R.C.J. 登録日 2023-08-23 公開日 2024-09-11 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Structure of isomerase domain of the nan-regulatory protein (NanR) from Streptococcus pneumoniae To Be Published

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