5Y12

Crystal structure of human FABP4 complexed with ligand 5-((4-methoxynaphthalene)-1-sulfonamido)pentanoic acid

Summary for 5Y12

• Entry DOI: 10.2210/pdb5y12/pdb
• Descriptor: Fatty acid-binding protein, adipocyte, 5-[(4-methoxynaphthalen-1-yl)sulfonylamino]pentanoic acid (3 entities in total)
• Functional Keywords: lipid binding protein, fabp4, inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 17248.66

Authors

Su, H.X.,Liu, Q.F.,Xu, Y.C. (deposition date: 2017-07-19, release date: 2018-06-06, Last modification date: 2024-03-27)

• Primary citation: Gao, D.D.,Dou, H.X.,Su, H.X.,Zhang, M.M.,Wang, T.,Liu, Q.F.,Cai, H.Y.,Ding, H.P.,Yang, Z.,Zhu, W.L.,Xu, Y.C.,Wang, H.Y.,Li, Y.X.; From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4; Eur J Med Chem, 154:44-59, 2018; PubMed: 29775936; DOI: 10.1016/j.ejmech.2018.05.007

Experimental method

X-RAY DIFFRACTION (1.75 Å)