PDB: 5425 件ウェブページステータス検索Chemie searchBIRD

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5L9T	Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density 分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... 著者 Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. 登録日 2016-06-11 公開日 2016-10-26 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (6.4 Å) 主引用文献 Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
2LXT	Allosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core 分子名称: CREB-binding protein, Cyclic AMP-responsive element-binding protein 1, Histone-lysine N-methyltransferase MLL 著者 Bruschweiler, S, Schanda, P, Konrat, R, Tollinger, M. 登録日 2012-08-31 公開日 2013-06-12 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Allosteric communication in the KIX domain proceeds through dynamic repacking of the hydrophobic core. Acs Chem.Biol., 8, 2013
6S4N	LXRbeta ligand binding domain in comlpex with small molecule inhibitors 分子名称: 2-[5-chloranyl-6-[4-[[1,1,3-tris(oxidanylidene)-5-phenyl-2-propan-2-yl-1,2-thiazol-4-yl]amino]piperidin-1-yl]pyridin-3-yl]ethanoic acid, Oxysterols receptor LXR-beta, SULFATE ION 著者 Sandmark, J, Jansson, A. 登録日 2019-06-28 公開日 2019-11-27 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands. Commun Biol, 2, 2019
7V7B	CryoEM structure of DDB1-VprBP complex in ARM-up conformation 分子名称: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1 著者 Wang, D, Xu, J, Liu, Q, Xiang, Y. 登録日 2021-08-21 公開日 2022-08-31 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
5LCW	Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic checkpoint complex (APC/C-MCC) at 4.2 angstrom resolution 分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... 著者 Alfieri, C, Chang, L, Zhang, Z, Yang, J, Maslen, S, Skehel, M, Barford, D. 登録日 2016-06-22 公開日 2016-08-10 最終更新日 2019-10-23 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Molecular basis of APC/C regulation by the spindle assembly checkpoint. Nature, 536, 2016
6S4U	LXRbeta ligand binding domain in comlpex with small molecule inhibitors 分子名称: 6-[4-[[3-oxidanyl-1,1-bis(oxidanylidene)-5-phenyl-2-propan-2-yl-3~{H}-1,2-thiazol-4-yl]amino]butyl]pyridine-2-sulfonamide, Oxysterols receptor LXR-beta 著者 Sandmark, J, Jansson, A. 登録日 2019-06-28 公開日 2019-11-27 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands. Commun Biol, 2, 2019
7SAN	Crystal structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with (4S,7S)-7-hydroxy-4-((guanin-9-yl)methyl)-2,5-dioxaheptan-1,7-diphosphonate 分子名称: ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase 著者 Guddat, L.W, Keough, D.T. 登録日 2021-09-22 公開日 2022-05-18 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.58155513 Å) 主引用文献 Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases. J.Med.Chem., 65, 2022
5LGT	Thieno[3,2-b]pyrrole-5-carboxamides as Novel Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1: Compound 15 分子名称: 4-methyl-~{N}-[2-[[4-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A, ... 著者 Mattevi, A, Ciossani, G. 登録日 2016-07-08 公開日 2017-02-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship. J. Med. Chem., 60, 2017
2MKN	Structural Characterization of Interactions between the Double-Stranded RNA-Binding Zinc Finger Protein JAZ and dsRNA 分子名称: RNA (5'-R(*GP*CP*CP*GP*UP*GP*GP*UP*CP*UP*GP*GP*UP*GP*GP*CP*CP*GP*G)-3'), RNA (5'-R(P*CP*CP*GP*GP*CP*CP*AP*CP*CP*AP*GP*AP*CP*CP*AP*CP*GP*GP*C)-3'), ZINC ION, ... 著者 Wright, P, Dyson, J, Burge, R, Martinez-Yamout, M. 登録日 2014-02-10 公開日 2014-03-19 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural Characterization of Interactions between the Double-Stranded RNA-Binding Zinc Finger Protein JAZ and Nucleic Acids. Biochemistry, 53, 2014
5LHG	Structure of the KDM1A/CoREST complex with the inhibitor 4-methyl-N-[4-[[4-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide 分子名称: 4-methyl-N-[4-[[4-[(1-methyl-4-piperidyl)oxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Cecatiello, V, Pasqualato, S. 登録日 2016-07-11 公開日 2017-02-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.34 Å) 主引用文献 Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship. J. Med. Chem., 60, 2017
5LT0	nucleotide-free kinesin-1 motor domain, P212121 crystal form 分子名称: ACETATE ION, Kinesin-like protein, STRONTIUM ION, ... 著者 Cao, L, Gigant, B. 登録日 2016-09-06 公開日 2017-03-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The structural switch of nucleotide-free kinesin. Sci Rep, 7, 2017
4HB2	Crystal structure of CRM1-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... 著者 Sun, Q, Chook, Y.M. 登録日 2012-09-27 公開日 2013-01-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
2MKD	Human JAZ ZF3 Residues 168-227 分子名称: ZINC ION, Zinc finger protein 346 著者 Wright, P, Dyson, J, Burge, R, Martinez-Yamout, M. 登録日 2014-02-05 公開日 2014-03-19 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural Characterization of Interactions between the Double-Stranded RNA-Binding Zinc Finger Protein JAZ and Nucleic Acids. Biochemistry, 53, 2014
7S7B	Human Nuclear exosome targeting (NEXT) complex homodimer bound to RNA (substrate 1) 分子名称: Exosome RNA helicase MTR4, RNA (46-MER), RNA-binding protein 7, ... 著者 Puno, M.R, Lima, C.D. 登録日 2021-09-15 公開日 2022-06-15 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (4.06 Å) 主引用文献 Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex. Cell, 185, 2022
7S7C	Human Nuclear Exosome Targeting (NEXT) complex bound to RNA (substrate 2) 分子名称: Exosome RNA helicase MTR4, RNA (30-MER), RNA-binding protein 7, ... 著者 Puno, M.R, Lima, C.D. 登録日 2021-09-15 公開日 2022-06-15 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.62 Å) 主引用文献 Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex. Cell, 185, 2022
4HAU	Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... 著者 Sun, Q, Chook, Y.M. 登録日 2012-09-27 公開日 2013-01-09 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
2MMC	Nucleotide-free human ran gtpase 分子名称: GTP-binding nuclear protein Ran 著者 Bacot-Davis, V.R, Palmenberg, A.C. 登録日 2014-03-13 公開日 2014-10-22 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Nuclear Magnetic Resonance Structure of Ran GTPase Determines C-terminal Tail Conformational Dynamics. To be Published
5LJ1	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one 分子名称: 1,2-ETHANEDIOL, 8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one, Bromodomain-containing protein 4 著者 Chung, C, Bamborough, P, Demont, E. 登録日 2016-07-17 公開日 2016-08-31 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A Chemical Probe for the ATAD2 Bromodomain. Angew.Chem.Int.Ed.Engl., 55, 2016
6RIH	Crystal structure of PHGDH in complex with compound 9 分子名称: D-3-phosphoglycerate dehydrogenase, SULFATE ION, ~{N}-cyclopropyl-2-methyl-5-phenyl-pyrazole-3-carboxamide 著者 Bader, G, Wolkerstorfer, B, Zoephel, A. 登録日 2019-04-24 公開日 2019-08-07 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis. J.Med.Chem., 62, 2019
5LNC	Structure of SPX domain of the yeast inorganic polyphophate polymerase Vtc4 crystallized by carrier-driven crystallization in fusion with the macro domain of human histone macroH2A1.1 分子名称: Vacuolar transporter chaperone 4,Core histone macro-H2A.1 著者 Wild, R, Hothorn, M. 登録日 2016-08-03 公開日 2016-11-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.29 Å) 主引用文献 The macro domain as fusion tag for carrier-driven crystallization. Protein Sci., 26, 2017
6XAU	Structure of the PR domain from PRDM3 分子名称: Histone-lysine N-methyltransferase MECOM 著者 Loa, S, Mou, T.C, Sprang, S.R, Briknarova, K. 登録日 2020-06-04 公開日 2021-06-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Structure of the PR domain from PRDM3 To Be Published
6RJ2	Crystal structure of PHGDH in complex with compound 40 分子名称: D-3-phosphoglycerate dehydrogenase, SULFATE ION, ~{N}-[(1~{R})-1-[4-(ethanoylsulfamoyl)phenyl]ethyl]-2-methyl-5-phenyl-pyrazole-3-carboxamide 著者 Bader, G, Wolkerstorfer, B, Zoephel, A. 登録日 2019-04-26 公開日 2019-08-07 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis. J.Med.Chem., 62, 2019
7RUI	Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with XR844 分子名称: Bromodomain-containing protein 4, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(5-{[(2-fluorophenyl)carbamoyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-indol-4-yl}-2,2,2-trifluoroethane-1-sulfonamide 著者 Ratia, K.M, Xiong, R, Li, Y, Shen, Z, Zhao, J, Huang, F, Dubrovyskyii, O, Thatcher, G.R. 登録日 2021-08-17 公開日 2022-08-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with XR844 To Be Published
7PCJ	X-ray structure of CypA-C52AK125C/CsA/aromatic foldamer complex 分子名称: 8-azanyl-4-(2-methylpropoxy)quinoline-2-carboxylic acid, 8-azanyl-4-(3-azanylpropoxy)quinoline-2-carboxylic acid, 8-azanyl-4-oxidanyl-quinoline-2-carboxylic acid, ... 著者 Vallade, M, Langlois d'Estaintot, B, Fischer, L, Buratto, J, Savko, M, Huc, I. 登録日 2021-08-03 公開日 2022-07-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 X-ray structure of a cystein mutant of Cyclophilin A tethered to an aromatic oligoamide foldamer complexed with Cyclosporin A To Be Published
7OZ0	Solution structure of the N-terminal domain of human telomeric Repeat-binding factor 2-interacting protein 1 (hRap1): implication for Rap1-TRF2 interaction in Human. 分子名称: Telomeric repeat-binding factor 2-interacting protein 1 著者 Miron, S, LeDU, M.H, Gaullier, G, Zinn-justin, S, Cuniasse, P. 登録日 2021-06-25 公開日 2022-10-05 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Solution structure of the N-terminal domain of human telomeric Repeat-binding factor 2-interacting protein 1 (hRap1): implication for Rap1-TRF2 interaction in Human. To Be Published

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