2LXT
Allosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core
Summary for 2LXT
Entry DOI | 10.2210/pdb2lxt/pdb |
Related | 2LXS |
NMR Information | BMRB: 18695 |
Descriptor | CREB-binding protein, Histone-lysine N-methyltransferase MLL, Cyclic AMP-responsive element-binding protein 1 (3 entities in total) |
Functional Keywords | creb binding protein, mixed-lineage leukemia activation domain, phosphorylated kinase inducible domain, creb, ternary complex, transferase-protein binding complex, transferase/protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: Q92793 Nucleus. MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164 Nucleus: P16220 |
Total number of polymer chains | 3 |
Total formula weight | 16359.48 |
Authors | Bruschweiler, S.,Schanda, P.,Konrat, R.,Tollinger, M. (deposition date: 2012-08-31, release date: 2013-06-12, Last modification date: 2023-06-14) |
Primary citation | Bruschweiler, S.,Konrat, R.,Tollinger, M. Allosteric communication in the KIX domain proceeds through dynamic repacking of the hydrophobic core. Acs Chem.Biol., 8:1600-1610, 2013 Cited by PubMed: 23651431DOI: 10.1021/cb4002188 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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