2LXT
Allosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | CREB-binding protein | polymer | 87 | 10353.9 | 1 | UniProt (Q92793) Pfam (PF02172) In PDB | Homo sapiens (human) | |
| 2 | B | Histone-lysine N-methyltransferase MLL | polymer | 19 | 2061.3 | 1 | UniProt (Q03164) In PDB | Homo sapiens (human) | ALL-1, CXXC-type zinc finger protein 7, Lysine N-methyltransferase 2A, KMT2A, Trithorax-like protein, Zinc finger protein HRX, MLL cleavage product N320, N-terminal cleavage product of 320 kDa, p320, MLL cleavage product C180, C-terminal cleavage product of 180 kDa, p180 |
| 3 | C | Cyclic AMP-responsive element-binding protein 1 | polymer | 34 | 3944.3 | 1 | UniProt (P16220) Pfam (PF02173) In PDB | Homo sapiens (human) | CREB-1, cAMP-responsive element-binding protein 1 |
Sequence modifications
B: 840 - 858 (UniProt: Q03164)
| PDB | External Database | Details |
|---|---|---|
| Ala 841 | Cys 2841 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 16359.5 | |
| All* | Total formula weight | 16359.5 |
