2LXS

Allosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core

Summary for 2LXS

• Entry DOI: 10.2210/pdb2lxs/pdb
• Related: 2LXT
• NMR Information: BMRB: 18694
• Descriptor: CREB-binding protein, Histone-lysine N-methyltransferase MLL (2 entities in total)
• Functional Keywords: creb binding protein, mixed-lineage leukemia activation domain, binary complex, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q92793; Nucleus. MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164
• Total number of polymer chains: 2
• Total formula weight: 12415.19

Authors

Bruschweiler, S.,Schanda, P.,Konrat, R.,Tollinger, M. (deposition date: 2012-08-31, release date: 2013-06-12, Last modification date: 2023-06-14)

• Primary citation: Bruschweiler, S.,Konrat, R.,Tollinger, M.; Allosteric communication in the KIX domain proceeds through dynamic repacking of the hydrophobic core.; Acs Chem.Biol., 8:1600-1610, 2013; PubMed: 23651431; DOI: 10.1021/cb4002188

Experimental method

SOLUTION NMR