2LXS
Allosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CREB-binding protein | polymer | 87 | 10353.9 | 1 | UniProt (Q92793) Pfam (PF02172) | Homo sapiens (human) | |
| 2 | B (B) | Histone-lysine N-methyltransferase MLL | polymer | 19 | 2061.3 | 1 | UniProt (Q03164) | Homo sapiens (human) | ALL-1, CXXC-type zinc finger protein 7, Lysine N-methyltransferase 2A, KMT2A, Trithorax-like protein, Zinc finger protein HRX, MLL cleavage product N320, N-terminal cleavage product of 320 kDa, p320, MLL cleavage product C180, C-terminal cleavage product of 180 kDa, p180 |
Sequence modifications
B: 840 - 858 (UniProt: Q03164)
| PDB | External Database | Details |
|---|---|---|
| Ala 841 | Cys 2841 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 12415.2 | |
| All* | Total formula weight | 12415.2 |
