4L4S
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![BU of 4l4s by Molmil](/molmil-images/mine/4l4s) | Structural characterisation of the NADH binary complex of human lactate dehydrogenase M isozyme | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-lactate dehydrogenase A chain | 著者 | Dempster, S, Harper, S, Moses, J.E, Dreveny, I. | 登録日 | 2013-06-09 | 公開日 | 2014-04-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase. Acta Crystallogr.,Sect.D, 70, 2014
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6J9D
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2X0I
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![BU of 2x0i by Molmil](/molmil-images/mine/2x0i) | 2.9 A RESOLUTION STRUCTURE OF MALATE DEHYDROGENASE FROM ARCHAEOGLOBUS FULGIDUS IN COMPLEX WITH NADH | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, MALATE DEHYDROGENASE, SODIUM ION, ... | 著者 | Irimia, A, Madern, D, Zaccai, G, Vellieux, F.M.D, Karshikoff, A, Tibbelin, G, Ladenstein, R, Lien, T, Birkeland, N.-K. | 登録日 | 2009-12-14 | 公開日 | 2009-12-22 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | The 2.9A Resolution Crystal Structure of Malate Dehydrogenase from Archaeoglobus Fulgidus: Mechanisms of Oligomerisation and Thermal Stabilisation. J.Mol.Biol., 335, 2004
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6SBU
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![BU of 6sbu by Molmil](/molmil-images/mine/6sbu) | X-ray Structure of Human LDHA with an Allosteric Inhibitor (Compound 3) | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-[[4-[(5-chloranylthiophen-2-yl)carbonylamino]-1,3-bis(oxidanylidene)isoindol-2-yl]methyl]benzoic acid, L-lactate dehydrogenase A chain | 著者 | Friberg, A, Puetter, V, Nguyen, D, Rehwinkel, H. | 登録日 | 2019-07-22 | 公開日 | 2020-06-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A. Acs Omega, 5, 2020
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2X0R
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![BU of 2x0r by Molmil](/molmil-images/mine/2x0r) | R207S, R292S Mutant of Malate Dehydrogenase from the Halophilic Archeon Haloarcula marismortui (HoloForm) | 分子名称: | CHLORIDE ION, MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Irimia, A, Ebel, C, Vellieux, F.M.D, Richard, S.B, Cosenza, L.W, Zaccai, G, Madern, D. | 登録日 | 2009-12-17 | 公開日 | 2009-12-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.915 Å) | 主引用文献 | The Oligomeric States of Haloarcula Marismortui Malate Dehydrogenase are Modulated by Solvent Components as Shown by Crystallographic and Biochemical Studies J.Mol.Biol., 326, 2003
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5ZJE
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![BU of 5zje by Molmil](/molmil-images/mine/5zje) | LDHA-mla | 分子名称: | L-lactate dehydrogenase A chain, MALONATE ION | 著者 | Han, C.W, Jang, S.B. | 登録日 | 2018-03-20 | 公開日 | 2019-07-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.929 Å) | 主引用文献 | Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid. Cancers (Basel), 11, 2019
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1D3A
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![BU of 1d3a by Molmil](/molmil-images/mine/1d3a) | CRYSTAL STRUCTURE OF THE WILD TYPE HALOPHILIC MALATE DEHYDROGENASE IN THE APO FORM | 分子名称: | CHLORIDE ION, HALOPHILIC MALATE DEHYDROGENASE, SODIUM ION | 著者 | Richard, S.B, Madern, D, Garcin, E, Zaccai, G. | 登録日 | 1999-09-28 | 公開日 | 2000-03-20 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Halophilic adaptation: novel solvent protein interactions observed in the 2.9 and 2.6 A resolution structures of the wild type and a mutant of malate dehydrogenase from Haloarcula marismortui. Biochemistry, 39, 2000
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2LDX
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9FEF
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![BU of 9fef by Molmil](/molmil-images/mine/9fef) | Cryo-EM structure of Trypanosoma cruzi (MDH)4-PEX5 complex | 分子名称: | Peroxisome targeting signal 1 receptor, malate dehydrogenase | 著者 | Lipinski, O, Sonani, R.R, Blat, A, Jemiola-Rzeminska, M, Patel, S.N, Sood, T, Dubin, G. | 登録日 | 2024-05-19 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Cryo-EM structure of Trypanosoma cruzi (MDH)4-PEX5 complex To Be Published
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5IXY
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![BU of 5ixy by Molmil](/molmil-images/mine/5ixy) | Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 31: (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one | 分子名称: | (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one, L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Chen, Z, Eigenbrot, C. | 登録日 | 2016-03-23 | 公開日 | 2016-09-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. Acs Med.Chem.Lett., 7, 2016
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8J5D
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![BU of 8j5d by Molmil](/molmil-images/mine/8j5d) | Cryo-EM structure of starch degradation complex of BAM1-LSF1-MDH | 分子名称: | Beta-amylase 1, chloroplastic, Malate dehydrogenase, ... | 著者 | Guan, Z.Y, Liu, J, Yan, J.J. | 登録日 | 2023-04-21 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | The LIKE SEX FOUR 1-malate dehydrogenase complex functions as a scaffold to recruit beta-amylase to promote starch degradation. Plant Cell, 36, 2023
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4QSM
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![BU of 4qsm by Molmil](/molmil-images/mine/4qsm) | Crystal structure of human muscle L-lactate dehydrogenase in complex with inhibitor 2, 3-{[7-(2,4-dimethoxypyrimidin-5-yl)-3-sulfamoylquinolin-4-yl]amino}benzoic acid | 分子名称: | 3-{[7-(2,4-dimethoxypyrimidin-5-yl)-3-sulfamoylquinolin-4-yl]amino}benzoic acid, L-lactate dehydrogenase A chain | 著者 | Kolappan, S, Craig, L. | 登録日 | 2014-07-06 | 公開日 | 2014-12-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallogr.,Sect.D, 71, 2015
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3LDH
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![BU of 3ldh by Molmil](/molmil-images/mine/3ldh) | A comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexes | 分子名称: | LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYRUVIC ACID | 著者 | White, J.L, Hackert, M.L, Buehner, M, Adams, M.J, Ford, G.C, Lentzjunior, P.J, Smiley, I.E, Steindel, S.J, Rossmann, M.G. | 登録日 | 1974-06-06 | 公開日 | 1977-04-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | A comparison of the structures of apo dogfish M4 lactate dehydrogenase and its ternary complexes. J.Mol.Biol., 102, 1976
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2LDB
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7EPM
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![BU of 7epm by Molmil](/molmil-images/mine/7epm) | human LDHC complexed with NAD+ and ethylamino acetic acid | 分子名称: | 2-(ethylamino)-2-oxidanylidene-ethanoic acid, L-lactate dehydrogenase C chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Yu, Y, Chen, Q. | 登録日 | 2021-04-27 | 公開日 | 2022-03-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Identification of human LDHC4 as a potential target for anticancer drug discovery. Acta Pharm Sin B, 12, 2022
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1LLC
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![BU of 1llc by Molmil](/molmil-images/mine/1llc) | STRUCTURE DETERMINATION OF THE ALLOSTERIC L-LACTATE DEHYDROGENASE FROM LACTOBACILLUS CASEI AT 3.0 ANGSTROMS RESOLUTION | 分子名称: | 1,6-di-O-phosphono-alpha-D-fructofuranose, L-LACTATE DEHYDROGENASE, SULFATE ION | 著者 | Buehner, M, Hecht, H.J, Hensel, R. | 登録日 | 1988-11-21 | 公開日 | 1989-07-12 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | STRUCTURE DETERMINATION OF THE ALLOSTERIC L-LACTATE DEHYDROGENASE FROM LACTOBACILLUS-CASEI AT 3A RESOLUTION. Acta Crystallogr.,Sect.A, 40, 1984
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1T2F
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![BU of 1t2f by Molmil](/molmil-images/mine/1t2f) | Human B lactate dehydrogenase complexed with NAD+ and 4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid | 分子名称: | 4-HYDROXY-1,2,5-OXADIAZOLE-3-CARBOXYLIC ACID, L-lactate dehydrogenase B chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Cameron, A, Read, J, Tranter, R, Winter, V.J, Sessions, R.B, Brady, R.L, Vivas, L, Easton, A, Kendrick, H, Croft, S.L, Barros, D, Lavandera, J.L, Martin, J.J, Risco, F, Garcia-Ochoa, S, Gamo, F.J, Sanz, L, Leon, L, Ruiz, J.R, Gabarro, R, Mallo, A, De Las Heras, F.G. | 登録日 | 2004-04-21 | 公開日 | 2004-05-11 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. J.Biol.Chem., 279, 2004
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4A73
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1Y6J
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![BU of 1y6j by Molmil](/molmil-images/mine/1y6j) | L-Lactate Dehydrogenase from Clostridium Thermocellum Cth-1135 | 分子名称: | L-lactate dehydrogenase | 著者 | Chen, L, Yang, H, Kataeva, I, Chen, L.R, Tempel, W, Lee, D, Habel, J, Zhou, W, Lin, D, Ljungdahl, L, Liu, Z.-J, Rose, J, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2004-12-06 | 公開日 | 2004-12-14 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | L-Lactate Dehydrogenase from Clostridium Thermocellum Cth-1135 To be Published
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9FEE
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![BU of 9fee by Molmil](/molmil-images/mine/9fee) | Cryo-EM structure of Trypanosoma cruzi glycosomal malate dehydrogenase | 分子名称: | malate dehydrogenase | 著者 | Lipinski, O, Sonani, R.R, Blat, A, Jemiola-Rzeminska, M, Patel, S.N, Sood, T, Dubin, G. | 登録日 | 2024-05-19 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Cryo-EM structure of Trypanosoma cruzi glycosomal malate dehydrogenase To Be Published
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8Q3C
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![BU of 8q3c by Molmil](/molmil-images/mine/8q3c) | Structure of Selenomonas ruminantium lactate dehydrogenase I85R mutant | 分子名称: | CHLORIDE ION, L-lactate dehydrogenase, NITRATE ION, ... | 著者 | Bertrand, Q, Coquille, S, Iorio, A, Sterpone, F, Madern, D. | 登録日 | 2023-08-03 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases. J.Struct.Biol., 215, 2023
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4R69
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![BU of 4r69 by Molmil](/molmil-images/mine/4r69) | Lactate Dehydrogenase in complex with inhibitor compound 13 | 分子名称: | (5R)-2-[(2-chlorophenyl)sulfanyl]-5-[2,6-dichloro-3-(tetrahydro-2H-pyran-4-ylamino)phenyl]-3-hydroxycyclohex-2-en-1-one, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Eigenbrot, C, Ultsch, M. | 登録日 | 2014-08-22 | 公開日 | 2014-12-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg.Med.Chem.Lett., 25, 2014
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4QT0
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![BU of 4qt0 by Molmil](/molmil-images/mine/4qt0) | Crystal structure of human muscle L-lactate dehydrogenase in complex with inhibitor 1, 3-{[3-CARBAMOYL-7-(2,4-DIMETHOXYPYRIMIDIN-5-YL)QUINOLIN-4-YL]AMINO}BENZOIC ACID | 分子名称: | 3-{[3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino}benzoic acid, L-lactate dehydrogenase A chain | 著者 | Kolappan, S, Craig, L. | 登録日 | 2014-07-06 | 公開日 | 2014-12-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallogr.,Sect.D, 71, 2015
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1HLP
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8GGH
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![BU of 8ggh by Molmil](/molmil-images/mine/8ggh) | Structure of Trypanosoma (MDH)4-PEX5, distal conformation | 分子名称: | Peroxisome targeting signal 1 receptor, malate dehydrogenase | 著者 | Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G. | 登録日 | 2023-03-08 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Structure of Trypanosoma (MDH)4-PEX5, distal conformation To Be Published
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