6SBU
X-ray Structure of Human LDHA with an Allosteric Inhibitor (Compound 3)
Summary for 6SBU
| Entry DOI | 10.2210/pdb6sbu/pdb |
| Descriptor | L-lactate dehydrogenase A chain, 4-[[4-[(5-chloranylthiophen-2-yl)carbonylamino]-1,3-bis(oxidanylidene)isoindol-2-yl]methyl]benzoic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... (4 entities in total) |
| Functional Keywords | ldha, oxidoreductase, oxidoreductase inhibitor, allosteric inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 8 |
| Total formula weight | 298141.95 |
| Authors | Friberg, A.,Puetter, V.,Nguyen, D.,Rehwinkel, H. (deposition date: 2019-07-22, release date: 2020-06-10, Last modification date: 2024-01-24) |
| Primary citation | Friberg, A.,Rehwinkel, H.,Nguyen, D.,Putter, V.,Quanz, M.,Weiske, J.,Eberspacher, U.,Heisler, I.,Langer, G. Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A. Acs Omega, 5:13034-13041, 2020 Cited by PubMed: 32548488DOI: 10.1021/acsomega.0c00715 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.91 Å) |
Structure validation
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