PDB: 395 件ウェブページステータス検索Chemie searchBIRD

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4K0V	Structural basis for angiopoietin-1 mediated signaling initiation 分子名称: Angiopoietin-1, TEK tyrosine kinase variant 著者 Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. 登録日 2013-04-04 公開日 2013-05-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (4.51 Å) 主引用文献 Structural basis for angiopoietin-1-mediated signaling initiation. Proc.Natl.Acad.Sci.USA, 110, 2013
4M4R	Epha4 ectodomain complex with ephrin a5 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-A receptor 4, ... 著者 Xu, K, Tsvetkova-Robev, D, Xu, Y, Goldgur, Y, Chan, Y.-P, Himanen, J.P, Nikolov, D.B. 登録日 2013-08-07 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.13 Å) 主引用文献 Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. Proc.Natl.Acad.Sci.USA, 110, 2013
6JK8	Cryo-EM structure of the full-length human IGF-1R in complex with insulin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ... 著者 Zhang, X, Yu, D, Wang, T. 登録日 2019-02-27 公開日 2020-03-04 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis. Structure, 28, 2020
1EER	CRYSTAL STRUCTURE OF HUMAN ERYTHROPOIETIN COMPLEXED TO ITS RECEPTOR AT 1.9 ANGSTROMS 分子名称: ERYTHROPOIETIN, ERYTHROPOIETIN RECEPTOR 著者 Syed, R.S, Li, C. 登録日 1998-07-24 公開日 1999-10-01 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature, 395, 1998
1EBA	COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN INACTIVE PEPTIDE [EMP33] CONTAINS 3,5-DIBROMOTYROSINE IN POSITION 4 (DENOTED DBY) 分子名称: PROTEIN (EPO MIMETICS PEPTIDE 33), PROTEIN (ERYTHROPOIETIN RECEPTOR) 著者 Livnah, O, Stura, E.A, Wilson, I.A. 登録日 1998-10-02 公開日 1998-11-11 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation. Nat.Struct.Biol., 5, 1998
1EBP	COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN AGONIST PEPTIDE [EMP1] 分子名称: EPO MIMETICS PEPTIDE 1, EPO RECEPTOR 著者 Livnah, O, Stura, E.A, Wilson, I.A. 登録日 1996-05-07 公開日 1997-07-29 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A. Science, 273, 1996
1ERN	NATIVE STRUCTURE OF THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] 分子名称: PROTEIN (ERYTHROPOIETIN RECEPTOR) 著者 Livnah, O, Stura, E.A, Wilson, I.A. 登録日 1999-01-11 公開日 2000-01-07 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science, 283, 1999
1F6F	CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR 分子名称: PLACENTAL LACTOGEN, PROLACTIN RECEPTOR 著者 Elkins, P.A, Christinger, H.W, Sandowski, Y, Sakal, E, Gertler, A, De Vos, A.M, Kossiakoff, A.A. 登録日 2000-06-21 公開日 2000-07-04 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor. Nat.Struct.Biol., 7, 2000
6MOH	Dimeric DARPin C_R3 complex with EpoR 分子名称: Dimeric DARPin E2C (C_R3), Erythropoietin receptor, PHOSPHATE ION, ... 著者 Jude, K.M, Mohan, K, Garcia, K.C. 登録日 2018-10-04 公開日 2019-06-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
6MOI	Dimeric DARPin C_angle_R5 complex with EpoR 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Dimeric DARPing CCR5 (C_angle_R5), ... 著者 Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. 登録日 2018-10-04 公開日 2019-06-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.065 Å) 主引用文献 Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
6MOK	Dimeric DARPin A_distance_R7 complex with EpoR 分子名称: Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor 著者 Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. 登録日 2018-10-04 公開日 2019-06-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (5.101 Å) 主引用文献 Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
6MOJ	Dimeric DARPin A_angle_R5 complex with EpoR 分子名称: D(-)-TARTARIC ACID, Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, ... 著者 Jude, K.M, Mohan, K, Garcia, K.C. 登録日 2018-10-04 公開日 2019-06-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.431 Å) 主引用文献 Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
6MOE	Monomeric DARPin E2 complex with EpoR 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E2 DARPin, ... 著者 Jude, K.M, Mohan, K, Garcia, K.C. 登録日 2018-10-04 公開日 2019-06-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.091 Å) 主引用文献 Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
1HWH	1:1 COMPLEX OF HUMAN GROWTH HORMONE MUTANT G120R WITH ITS SOLUBLE BINDING PROTEIN 分子名称: GROWTH HORMONE, GROWTH HORMONE BINDING PROTEIN 著者 Sundstrom, S.M, Lundqvist, T. 登録日 1996-11-13 公開日 1997-11-19 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution. J.Biol.Chem., 271, 1996
6MOL	Monoextended DARPin M_R12 complex with EpoR 分子名称: Erythropoietin receptor, GLYCEROL, Monoextended DARPin R12 (M_R12) 著者 Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. 登録日 2018-10-04 公開日 2019-06-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.163 Å) 主引用文献 Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
6MOF	Monomeric DARPin G2 complex with EpoR 分子名称: 1,2-ETHANEDIOL, Erythropoietin receptor, G2 DARPin 著者 Jude, K.M, Mohan, K, Garcia, K.C. 登録日 2018-10-04 公開日 2019-06-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.894 Å) 主引用文献 Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
1HWG	1:2 COMPLEX OF HUMAN GROWTH HORMONE WITH ITS SOLUBLE BINDING PROTEIN 分子名称: GROWTH HORMONE, GROWTH HORMONE BINDING PROTEIN 著者 Sundstrom, S.M, Lundqvist, T. 登録日 1996-11-13 公開日 1997-11-19 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution. J.Biol.Chem., 271, 1996
6NAJ	Integrin AlphaVBeta3 ectodomain bound to Hr10 variant of the 10th domain of Fibronectin. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ... 著者 van Agthoven, J, Arnaout, M.A. 登録日 2018-12-05 公開日 2019-12-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure-guided design of pure orthosteric inhibitors of alpha IIb beta 3 that prevent thrombosis but preserve hemostasis. Nat Commun, 11, 2020
1I1R	CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX 分子名称: INTERLEUKIN-6 RECEPTOR BETA CHAIN, VIRAL IL-6 著者 Chow, D, He, X, Snow, A.L, Rose-John, S, Garcia, K.C. 登録日 2001-02-02 公開日 2001-03-28 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of an extracellular gp130 cytokine receptor signaling complex. Science, 291, 2001
5FMV	Crystal structure of human CD45 extracellular region, domains d1-d4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C, SULFATE ION 著者 Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. 登録日 2015-11-09 公開日 2016-03-23 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'. Nat.Immunol., 17, 2016
5FN6	Crystal structure of human CD45 extracellular region, domains d1-d3 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C 著者 Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. 登録日 2015-11-10 公開日 2016-03-23 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'. Nat.Immunol., 17, 2016
5FM5	Crystal structure of the myomesin:obscurin-like-1 complex 分子名称: MYOMESIN-1, OBSCURIN-LIKE-1 著者 Pernigo, S, Steiner, R.A. 登録日 2015-11-01 公開日 2016-11-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection. Structure, 25, 2017
7U7N	IL-27 quaternary receptor signaling complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ... 著者 Caveney, N.A, Glassman, C.R, Jude, K.M, Tsutsumi, N, Garcia, K.C. 登録日 2022-03-07 公開日 2022-05-25 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 Structure of the IL-27 quaternary receptor signaling complex. Elife, 11, 2022
7U6E	Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IM462, ... 著者 Kirk, N.S, Lawrence, M.C. 登録日 2022-03-03 公開日 2022-10-05 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Activation of the human insulin receptor by non-insulin-related peptides Nat Commun, 13, 2022
7U6D	Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM459 分子名称: IM459, Isoform Short of Insulin receptor 著者 Kirk, N.S, Lawrence, M.C. 登録日 2022-03-03 公開日 2022-10-05 実験手法 ELECTRON MICROSCOPY (5.03 Å) 主引用文献 Activation of the human insulin receptor by non-insulin-related peptides Nat Commun, 13, 2022

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