8SP8
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![BU of 8sp8 by Molmil](/molmil-images/mine/8sp8) | Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV) | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHLORIDE ION, ... | 著者 | Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2023-05-02 | 公開日 | 2023-08-23 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin. Nat Commun, 14, 2023
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8JEU
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8JEC
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8JET
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8GKA
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![BU of 8gka by Molmil](/molmil-images/mine/8gka) | Human TRPV3 tetramer structure, closed conformation | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Lansky, S, Betancourt, J.M, Scheuring, S. | 登録日 | 2023-03-17 | 公開日 | 2023-09-06 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | 主引用文献 | A pentameric TRPV3 channel with a dilated pore. Nature, 621, 2023
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8GKG
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8FFO
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![BU of 8ffo by Molmil](/molmil-images/mine/8ffo) | |
8FHH
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8FHI
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![BU of 8fhi by Molmil](/molmil-images/mine/8fhi) | Wildtype rabbit TRPV5 in nanodiscs in complex with oleoyl coenzyme A, Open stated | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ERGOSTEROL, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name), ... | 著者 | De Jesus-Perez, J.J, Moiseenkova-Bell, V.Y. | 登録日 | 2022-12-14 | 公開日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A. Nat Commun, 14, 2023
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8JKM
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![BU of 8jkm by Molmil](/molmil-images/mine/8jkm) | RN-1747 bound state of mTRPV4 | 分子名称: | Transient receptor potential cation channel subfamily V member 4 | 著者 | Zhen, W.X, Yang, F. | 登録日 | 2023-06-01 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | 主引用文献 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8SWI
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8TF3
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![BU of 8tf3 by Molmil](/molmil-images/mine/8tf3) | Wildtype rabbit TRPV5 into nanodiscs in complex with econazole | 分子名称: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, ERGOSTEROL, ... | 著者 | De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y. | 登録日 | 2023-07-07 | 公開日 | 2024-01-10 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Structural mechanism of TRPV5 inhibition by econazole. Structure, 32, 2024
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8TF2
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8TF4
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![BU of 8tf4 by Molmil](/molmil-images/mine/8tf4) | Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and econazole | 分子名称: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, ERGOSTEROL, ... | 著者 | De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y. | 登録日 | 2023-07-07 | 公開日 | 2024-01-10 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structural mechanism of TRPV5 inhibition by econazole. Structure, 32, 2024
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8FFQ
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![BU of 8ffq by Molmil](/molmil-images/mine/8ffq) | Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and ruthenium red | 分子名称: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ERGOSTEROL, Transient receptor potential cation channel subfamily V member 5, ... | 著者 | De Jesus-Perez, J.J, Fluck, E.C, Pumroy, R.A, Protopopova, A.D, Rocereta, J.A, Moiseenkova-Bell, V.Y. | 登録日 | 2022-12-09 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Molecular details of ruthenium red pore block in TRPV channels. Embo Rep., 25, 2024
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8FFN
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![BU of 8ffn by Molmil](/molmil-images/mine/8ffn) | RR-bound wildtype rabbit TRPV5 in nanodiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ERGOSTEROL, Transient receptor potential cation channel subfamily V member 5, ... | 著者 | Fluck, E.C, De Jesus-Perez, J.J, Pumroy, R.A, Protopopova, A.D, Rocereta, J.A, Moiseenkova-Bell, V.Y. | 登録日 | 2022-12-09 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Molecular details of ruthenium red pore block in TRPV channels. Embo Rep., 25, 2024
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8SR6
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8WTZ
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![BU of 8wtz by Molmil](/molmil-images/mine/8wtz) | potassium outward rectifier channel SKOR | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Potassium channel SKOR | 著者 | Gao, X, Sun, T, Lu, Y, Jia, Y, Xu, X, Zhang, Y, Fu, P, Yang, G. | 登録日 | 2023-10-19 | 公開日 | 2024-04-10 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural changes in the conversion of an Arabidopsis outward-rectifying K + channel into an inward-rectifying channel. Plant Commun., 5, 2024
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8WUI
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![BU of 8wui by Molmil](/molmil-images/mine/8wui) | SKOR D312N L271P double mutation | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Potassium channel SKOR | 著者 | Gao, X, Sun, T, Lu, Y, Jia, Y, Xu, X, Zhang, Y, Fu, P, Yang, G. | 登録日 | 2023-10-20 | 公開日 | 2024-04-10 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural changes in the conversion of an Arabidopsis outward-rectifying K + channel into an inward-rectifying channel. Plant Commun., 5, 2024
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8V6M
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![BU of 8v6m by Molmil](/molmil-images/mine/8v6m) | Inactivated-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Tetrahydrocannabivarin, ... | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-12-01 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | 主引用文献 | TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site. Sci Adv, 10, 2024
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8V6L
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![BU of 8v6l by Molmil](/molmil-images/mine/8v6l) | Open-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Tetrahydrocannabivarin, ... | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-12-01 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site. Sci Adv, 10, 2024
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8V6K
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8V6O
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![BU of 8v6o by Molmil](/molmil-images/mine/8v6o) | Inactivated-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-aminoethyl diphenylborinate, SODIUM ION, ... | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-12-01 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site. Sci Adv, 10, 2024
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8V6N
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![BU of 8v6n by Molmil](/molmil-images/mine/8v6n) | Open-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-aminoethyl diphenylborinate, ARACHIDONIC ACID, ... | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-12-01 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | 主引用文献 | TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site. Sci Adv, 10, 2024
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8T0E
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![BU of 8t0e by Molmil](/molmil-images/mine/8t0e) | TRPV1 in Nanodisc not bound with lysophosphatidic acid (apo) | 分子名称: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1 | 著者 | Arnold, W.R, Cheng, Y. | 登録日 | 2023-05-31 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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