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8FHI
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Wildtype rabbit TRPV5 in nanodiscs in complex with oleoyl coenzyme A, Open stated
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ERGOSTEROL, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name), ...
著者De Jesus-Perez, J.J, Moiseenkova-Bell, V.Y.
登録日2022-12-14
公開日2023-11-01
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A.
Nat Commun, 14, 2023
8JKM
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RN-1747 bound state of mTRPV4
分子名称: Transient receptor potential cation channel subfamily V member 4
著者Zhen, W.X, Yang, F.
登録日2023-06-01
公開日2023-12-13
実験手法ELECTRON MICROSCOPY (3.98 Å)
主引用文献Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel.
Cell Discov, 9, 2023
8SWI
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Crystal structure of legAS4 from Legionella pneumophila subsp. pneumophila with histone H3 (1-12)peptide
分子名称: Eukaryotic huntingtin interacting protein B, Histone H3 peptided, S-ADENOSYL-L-HOMOCYSTEINE
著者Xu, C, Chung, I.Y.W, Cygler, M.
登録日2023-05-18
公開日2023-12-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin.
Mbio, 14, 2023
8TF4
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Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and econazole
分子名称: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, ERGOSTEROL, ...
著者De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y.
登録日2023-07-07
公開日2024-01-10
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Structural mechanism of TRPV5 inhibition by econazole.
Structure, 32, 2024
8TF2
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Wildtype rabbit TRPV5 into nanodiscs in Apo state
分子名称: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ERGOSTEROL, Transient receptor potential cation channel subfamily V member 5
著者De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y.
登録日2023-07-07
公開日2024-01-10
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.57 Å)
主引用文献Structural mechanism of TRPV5 inhibition by econazole.
Structure, 32, 2024
8TF3
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Wildtype rabbit TRPV5 into nanodiscs in complex with econazole
分子名称: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, ERGOSTEROL, ...
著者De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y.
登録日2023-07-07
公開日2024-01-10
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Structural mechanism of TRPV5 inhibition by econazole.
Structure, 32, 2024
8FFQ
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Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and ruthenium red
分子名称: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ERGOSTEROL, Transient receptor potential cation channel subfamily V member 5, ...
著者De Jesus-Perez, J.J, Fluck, E.C, Pumroy, R.A, Protopopova, A.D, Rocereta, J.A, Moiseenkova-Bell, V.Y.
登録日2022-12-09
公開日2024-02-07
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (2.65 Å)
主引用文献Molecular details of ruthenium red pore block in TRPV channels.
Embo Rep., 25, 2024
8FFN
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RR-bound wildtype rabbit TRPV5 in nanodiscs
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ERGOSTEROL, Transient receptor potential cation channel subfamily V member 5, ...
著者Fluck, E.C, De Jesus-Perez, J.J, Pumroy, R.A, Protopopova, A.D, Rocereta, J.A, Moiseenkova-Bell, V.Y.
登録日2022-12-09
公開日2024-02-07
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (2.96 Å)
主引用文献Molecular details of ruthenium red pore block in TRPV channels.
Embo Rep., 25, 2024
8SR6
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Crystal structure of legAS4 from Legionella pneumophila subsp. pneumophila with histone H3 (3-17)peptide
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Eukaryotic huntingtin interacting protein B, ...
著者Xu, C, Chung, I.Y.W, Cygler, M.
登録日2023-05-05
公開日2024-03-13
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Histone methyltransferase activity of the secreted Legionella pneumophila SET-domain effector RomA/LegAS4 depends on its ankyrin domain
To Be Published
8WUI
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SKOR D312N L271P double mutation
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Potassium channel SKOR
著者Gao, X, Sun, T, Lu, Y, Jia, Y, Xu, X, Zhang, Y, Fu, P, Yang, G.
登録日2023-10-20
公開日2024-04-10
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural changes in the conversion of an Arabidopsis outward-rectifying K + channel into an inward-rectifying channel.
Plant Commun., 2024
8WTZ
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potassium outward rectifier channel SKOR
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Potassium channel SKOR
著者Gao, X, Sun, T, Lu, Y, Jia, Y, Xu, X, Zhang, Y, Fu, P, Yang, G.
登録日2023-10-19
公開日2024-04-10
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural changes in the conversion of an Arabidopsis outward-rectifying K + channel into an inward-rectifying channel.
Plant Commun., 2024
8V6O
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Inactivated-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-aminoethyl diphenylborinate, SODIUM ION, ...
著者Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
登録日2023-12-01
公開日2024-04-17
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site.
Sci Adv, 10, 2024
8V6N
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Open-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-aminoethyl diphenylborinate, ARACHIDONIC ACID, ...
著者Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
登録日2023-12-01
公開日2024-04-17
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (2.59 Å)
主引用文献TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site.
Sci Adv, 10, 2024
8V6L
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Open-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Tetrahydrocannabivarin, ...
著者Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
登録日2023-12-01
公開日2024-04-17
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.68 Å)
主引用文献TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site.
Sci Adv, 10, 2024
8V6M
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Inactivated-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Tetrahydrocannabivarin, ...
著者Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
登録日2023-12-01
公開日2024-04-17
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.63 Å)
主引用文献TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site.
Sci Adv, 10, 2024
8V6K
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Apo-state cryo-EM structure of human TRPV3 in cNW30 nanodiscs
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3
著者Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
登録日2023-12-01
公開日2024-04-17
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (2.46 Å)
主引用文献TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site.
Sci Adv, 10, 2024
8T0Y
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TRPV1 in nanodisc bound with one LPA in one monomer
分子名称: (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ...
著者Arnold, W.R, Cheng, Y.
登録日2023-06-01
公開日2024-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
8T3L
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TRPV1 in nanodisc bound with 2 LPA molecules in neighboring monomers
分子名称: (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ...
著者Arnold, W.R, Julius, D, Cheng, Y.
登録日2023-06-07
公開日2024-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
8T0E
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TRPV1 in Nanodisc not bound with lysophosphatidic acid (apo)
分子名称: (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1
著者Arnold, W.R, Cheng, Y.
登録日2023-05-31
公開日2024-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
8T3M
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TRPV1 in nanodisc bound with 3 LPA molecules
分子名称: (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ...
著者Arnold, W.R, Julius, D, Cheng, Y.
登録日2023-06-07
公開日2024-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
8T0C
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TRPV1 in Nanodisc bound with lysophosphatidic acid in all four monomers
分子名称: (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1
著者Arnold, W.R, Cheng, Y.
登録日2023-05-31
公開日2024-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
8T10
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TRPV1 in nanodisc bound with two LPA molecules in opposite monomers
分子名称: (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ...
著者Arnold, W.R, Julius, D, Cheng, Y.
登録日2023-06-01
公開日2024-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
8JVI
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Structure of human TRPV4 with antagonist A2
分子名称: Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone
著者Fan, J, Lei, X.
登録日2023-06-28
公開日2024-05-08
実験手法ELECTRON MICROSCOPY (3.21 Å)
主引用文献Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 2024
8JVJ
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Structure of human TRPV4 with antagonist A2 and RhoA
分子名称: Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone
著者Fan, J, Lei, X.
登録日2023-06-28
公開日2024-05-08
実験手法ELECTRON MICROSCOPY (3.44 Å)
主引用文献Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 2024
8JU5
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Structure of human TRPV4 with antagonist A1
分子名称: 4-[(3~{S},4~{S})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP
著者Fan, J, Lei, X.
登録日2023-06-24
公開日2024-05-08
実験手法ELECTRON MICROSCOPY (3.74 Å)
主引用文献Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 2024

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件を2024-06-12に公開中

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