8SP8

Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV)

Summary for 8SP8

Entry DOI	10.2210/pdb8sp8/pdb
EMDB information	40676
Descriptor	Transient receptor potential cation channel subfamily V member 6, CHOLESTEROL HEMISUCCINATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ... (6 entities in total)
Functional Keywords	phyto-cannabinoid, phytocannabinoid, cannabindoid, tetrahydrocannabivarin, thcv, transient receptor potential v family member 6, trp, human, channel, closed, trpv6, trp channels, cancer, oncochannel, membrane protein, cnw30, nanodiscs, circularized nanodiscs, nanodisc, vanilloid
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	335710.45
Authors	Neuberger, A.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Sobolevsky, A.I. (deposition date: 2023-05-02, release date: 2023-08-23)
Primary citation	Neuberger, A.,Trofimov, Y.A.,Yelshanskaya, M.V.,Khau, J.,Nadezhdin, K.D.,Khosrof, L.S.,Krylov, N.A.,Efremov, R.G.,Sobolevsky, A.I. Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin. Nat Commun, 14:4630-4630, 2023 Cited by PubMed: 37532722 DOI: 10.1038/s41467-023-40362-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.79 Å)

Structure validation