PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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4I20	Crystal structure of monomeric (V948R) primary oncogenic mutant L858R EGFR kinase domain 分子名称: Epidermal growth factor receptor 著者 Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. 登録日 2012-11-21 公開日 2013-01-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.34 Å) 主引用文献 Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21, 2013
4I24	Structure of T790M EGFR kinase domain co-crystallized with dacomitinib 分子名称: (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide, Epidermal growth factor receptor 著者 Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. 登録日 2012-11-21 公開日 2013-01-16 最終更新日 2013-02-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21, 2013
4HY2	Crystal structure of Plk1 Polo-box domain in complex with PL-42 分子名称: PL-42, Serine/threonine-protein kinase PLK1 著者 Lee, W.C, Song, J.H, Kim, H.Y. 登録日 2012-11-12 公開日 2013-04-03 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1. Bioorg.Med.Chem., 21, 2013
1JMG	CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN-229 MUTANTS OF THYMIDYLATE SYNTHASE 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R.M. 登録日 1997-09-13 公開日 1998-01-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase. J.Mol.Biol., 276, 1998
1JBT	CRYSTAL STRUCTURE OF RIBOTOXIN RESTRICTOCIN COMPLEXED WITH A 29-MER SARCIN/RICIN DOMAIN RNA ANALOG 分子名称: 29-MER SARCIN/RICIN DOMAIN RNA ANALOG, POTASSIUM ION, RESTRICTOCIN 著者 Yang, X, Gerczei, T, Glover, L, Correll, C.C. 登録日 2001-06-06 公開日 2001-10-26 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structures of restrictocin-inhibitor complexes with implications for RNA recognition and base flipping. Nat.Struct.Biol., 8, 2001
1TH8	Crystal Structures of the ADP and ATP bound forms of the Bacillus Anti-sigma factor SpoIIAB in complex with the Anti-anti-sigma SpoIIAA: inhibitory complex with ADP, crystal form II 分子名称: ADENOSINE-5'-DIPHOSPHATE, Anti-sigma F factor, Anti-sigma F factor antagonist, ... 著者 Masuda, S, Murakami, K.S, Wang, S, Olson, C.A, Donigian, J, Leon, F, Darst, S.A, Campbell, E.A. 登録日 2004-06-01 公開日 2004-06-15 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structures of the ADP and ATP Bound Forms of the Bacillus Anti-sigma Factor SpoIIAB in Complex with the Anti-anti-sigma SpoIIAA. J.Mol.Biol., 340, 2004
3VBX	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design 分子名称: 6-bromo-4-hydroxy-2H-chromen-2-one, Serine/threonine-protein kinase pim-1 著者 Liu, J. 登録日 2012-01-02 公開日 2012-03-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012
3VC4	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design 分子名称: (5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione, IMIDAZOLE, Serine/threonine-protein kinase pim-1 著者 Liu, J. 登録日 2012-01-03 公開日 2012-03-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012
1JBR	Crystal Structure of the Ribotoxin Restrictocin and a 31-mer SRD RNA Inhibitor 分子名称: 31-mer SRD RNA analog, 5'-R(*GP*CP*GP*CP*UP*CP*CP*UP*CP*AP*GP*UP*AP*CP*GP*AP*GP*(A23))-3', 5'-R(*GP*GP*AP*AP*CP*CP*GP*GP*AP*GP*CP*GP*C)-3', ... 著者 Yang, X, Gerczei, T, Glover, L, Correll, C.C. 登録日 2001-06-06 公開日 2001-10-26 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal structures of restrictocin-inhibitor complexes with implications for RNA recognition and base flipping. Nat.Struct.Biol., 8, 2001
2NRR	Crystal structure of the C-terminal RNAseH endonuclase domain of UvrC 分子名称: UvrABC system protein C 著者 Karakas, E, Truglio, J.J, Kisker, C. 登録日 2006-11-02 公開日 2007-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad. Embo J., 26, 2007
4LL0	EGFR L858R/T790M in complex with PD168393 分子名称: Epidermal growth factor receptor, N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide 著者 Yun, C.H, Eck, M.J. 登録日 2013-07-09 公開日 2013-09-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Mechanism for activation of mutated epidermal growth factor receptors in lung cancer. Proc.Natl.Acad.Sci.USA, 110, 2013
2NRX	Crystal structure of the C-terminal half of UvrC, in the presence of sulfate molecules 分子名称: GLYCEROL, SULFATE ION, UvrABC system protein C 著者 Karakas, E, Truglio, J.J, Kisker, C. 登録日 2006-11-02 公開日 2007-02-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad. Embo J., 26, 2007
4I58	Cyclohexylamine Oxidase from Brevibacterium oxydans IH-35A 分子名称: Cyclohexylamine Oxidase, FLAVIN-ADENINE DINUCLEOTIDE 著者 Mirza, I.A, Berghuis, A.M. 登録日 2012-11-28 公開日 2013-05-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural Analysis of a Novel Cyclohexylamine Oxidase from Brevibacterium oxydans IH-35A. Plos One, 8, 2013
1JIZ	Crystal Structure Analysis of human Macrophage Elastase MMP-12 分子名称: CALCIUM ION, N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE, ZINC ION, ... 著者 Nar, H, Werle, K, Bauer, M.M.T, Dollinger, H, Jung, B. 登録日 2001-07-03 公開日 2002-07-03 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor. J.Mol.Biol., 312, 2001
4HTT	Crystal Structure of Twin Arginine Translocase Receptor- TatC in DDM 分子名称: Sec-independent protein translocase protein TatC, Lysozyme 著者 Ramasamy, S, Suloway, C.J.M, Clemons Jr, W.M. 登録日 2012-11-01 公開日 2013-05-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (6.8 Å) 主引用文献 The Glove-like Structure of the Conserved Membrane Protein TatC Provides Insight into Signal Sequence Recognition in Twin-Arginine Translocation. Structure, 21, 2013
4I22	Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib 分子名称: Epidermal growth factor receptor, Gefitinib, SULFATE ION 著者 Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. 登録日 2012-11-21 公開日 2013-01-16 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21, 2013
4LGB	ABA-mimicking ligand N-(1-METHYL-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-(4-METHYLPHENYL)METHANESULFONAMIDE in complex with ABA receptor PYL2 and PP2C HAB1 分子名称: Abscisic acid receptor PYL2, MAGNESIUM ION, N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-1-(4-methylphenyl)methanesulfonamide, ... 著者 Zhou, X.E, Gao, M, Liu, X, Zhang, Y, Xue, X, Melcher, K, Gao, P, Wang, F, Zeng, L, Zhao, Y, Zhao, Y, Deng, P, Zhong, D, Zhu, J.-K, Xu, Y, Xu, H.E. 登録日 2013-06-27 公開日 2013-08-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Res., 23, 2013
4LFX	X-ray structure of the adduct between hen egg white lysozyme and Auoxo6, a dinuclear gold(III) complex with -dioxo bridges linking the two metal centers 分子名称: CHLORIDE ION, GOLD ION, Lysozyme C, ... 著者 Vergara, A, Merlino, A. 登録日 2013-06-27 公開日 2013-10-02 最終更新日 2013-10-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The mode of action of anticancer gold-based drugs: a structural perspective. Chem.Commun.(Camb.), 49, 2013
4LFP	X-ray structure of the adduct between hen egg white lysozyme and a homoleptic gold(I) complex with the saccharynate ligand 分子名称: CHLORIDE ION, GOLD ION, Lysozyme C, ... 著者 Vergara, A, Merlino, A. 登録日 2013-06-27 公開日 2013-10-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 The mode of action of anticancer gold-based drugs: a structural perspective. Chem.Commun.(Camb.), 49, 2013
4LG5	ABA-mimicking ligand QUINABACTIN in complex with ABA receptor PYL2 and PP2C HAB1 分子名称: Abscisic acid receptor PYL2, MAGNESIUM ION, Protein phosphatase 2C 16, ... 著者 Zhou, X.E, Gao, M, Liu, X, Zhang, Y, Xue, X, Melcher, K, Gao, P, Wang, F, Zeng, L, Zhao, Y, Zhao, Y, Deng, P, Zhong, D, Zhu, J.-K, Xu, Y, Xu, H.E. 登録日 2013-06-27 公開日 2013-08-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Res., 23, 2013
4LGA	ABA-mimicking ligand N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE in complex with ABA receptor PYL2 and PP2C HAB1 分子名称: Abscisic acid receptor PYL2, MAGNESIUM ION, N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)-1-phenylmethanesulfonamide, ... 著者 Zhou, X.E, Gao, M, Liu, X, Zhang, Y, Xue, X, Melcher, K, Gao, P, Wang, F, Zeng, L, Zhao, Y, Zhao, Y, Deng, P, Zhong, D, Zhu, J.-K, Xu, Y, Xu, H.E. 登録日 2013-06-27 公開日 2013-08-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Res., 23, 2013
4LKM	Crystal structure of Plk1 Polo-box domain in complex with PL-74 分子名称: GLYCEROL, PL-74, SULFATE ION, ... 著者 Lee, W.C, Song, J.H, Kim, H.Y. 登録日 2013-07-08 公開日 2013-12-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1 Plos One, 8, 2013
4LKL	Crystal structure of Plk1 Polo-box domain in complex with PL-55 分子名称: ADAMANTANE, PL-55, Serine/threonine-protein kinase PLK1 著者 Lee, W.C, Song, J.H, Kim, H.Y. 登録日 2013-07-08 公開日 2013-12-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1 Plos One, 8, 2013
2NRV	Crystal structure of the C-terminal half of UvrC 分子名称: SODIUM ION, UvrABC system protein C 著者 Karakas, E, Truglio, J.J, Kisker, C. 登録日 2006-11-02 公開日 2007-02-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad. Embo J., 26, 2007
1JH6	Semi-reduced Cyclic Nucleotide Phosphodiesterase from Arabidopsis thaliana 分子名称: SULFATE ION, cyclic phosphodiesterase 著者 Hofmann, A, Grella, M, Botos, I, Filipowicz, W, Wlodawer, A. 登録日 2001-06-27 公開日 2002-02-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thaliana. J.Biol.Chem., 277, 2002

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