4LFP

X-ray structure of the adduct between hen egg white lysozyme and a homoleptic gold(I) complex with the saccharynate ligand

Summary for 4LFP

Entry DOI	10.2210/pdb4lfp/pdb
Related	4J1A 4J1B 4LFX 4LGK
Descriptor	Lysozyme C, GOLD ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	hydrolase
Biological source	Gallus gallus (bantam,chickens)
Cellular location	Secreted: P00698
Total number of polymer chains	1
Total formula weight	14657.48
Authors	Vergara, A.,Merlino, A. (deposition date: 2013-06-27, release date: 2013-10-02, Last modification date: 2024-10-16)
Primary citation	Messori, L.,Scaletti, F.,Massai, L.,Cinellu, M.A.,Gabbiani, C.,Vergara, A.,Merlino, A. The mode of action of anticancer gold-based drugs: a structural perspective. Chem.Commun.(Camb.), 49:10100-10102, 2013 Cited by PubMed Abstract: The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes. PubMed: 24045294 DOI: 10.1039/c3cc46400h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation