4I24

Structure of T790M EGFR kinase domain co-crystallized with dacomitinib

Summary for 4I24

• Entry DOI: 10.2210/pdb4i24/pdb
• Related: 4I1Z 4I20 4I21 4I22 4I23
• Descriptor: Epidermal growth factor receptor, (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide (3 entities in total)
• Functional Keywords: kinase domain, phosphotrasfer, atp binding, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 2
• Total formula weight: 75896.59

Authors

Gajiwala, K.S.,Feng, J.,Ferre, R.,Ryan, K.,Brodsky, O.,Stewart, A. (deposition date: 2012-11-21, release date: 2013-01-16, Last modification date: 2013-02-27)

• Primary citation: Gajiwala, K.S.,Feng, J.,Ferre, R.,Ryan, K.,Brodsky, O.,Weinrich, S.,Kath, J.C.,Stewart, A.; Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition.; Structure, 21:209-219, 2013; PubMed: 23273428; DOI: 10.1016/j.str.2012.11.014

Experimental method

X-RAY DIFFRACTION (1.8 Å)