4I20

Crystal structure of monomeric (V948R) primary oncogenic mutant L858R EGFR kinase domain

Summary for 4I20

Entry DOI	10.2210/pdb4i20/pdb
Related	4I1Z 4I21 4I22 4I23 4I24
Descriptor	Epidermal growth factor receptor (1 entity in total)
Functional Keywords	kinase domain, phosphotransfer, atp binding, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	37550.36
Authors	Gajiwala, K.S.,Feng, J.,Ferre, R.,Ryan, K.,Brodsky, O.,Stewart, A. (deposition date: 2012-11-21, release date: 2013-01-16, Last modification date: 2024-02-28)
Primary citation	Gajiwala, K.S.,Feng, J.,Ferre, R.,Ryan, K.,Brodsky, O.,Weinrich, S.,Kath, J.C.,Stewart, A. Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21:209-219, 2013 Cited by PubMed: 23273428 DOI: 10.1016/j.str.2012.11.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.34 Å)

Structure validation