4I22

Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib

Summary for 4I22

Entry DOI	10.2210/pdb4i22/pdb
Related	4I1Z 4I20 4I21 4I23 4I24
Descriptor	Epidermal growth factor receptor, Gefitinib, SULFATE ION, ... (4 entities in total)
Functional Keywords	kinase domain, phosphotrasfer, atp binding, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	38219.48
Authors	Gajiwala, K.S.,Feng, J.,Ferre, R.,Ryan, K.,Brodsky, O.,Stewart, A. (deposition date: 2012-11-21, release date: 2013-01-16, Last modification date: 2024-03-27)
Primary citation	Gajiwala, K.S.,Feng, J.,Ferre, R.,Ryan, K.,Brodsky, O.,Weinrich, S.,Kath, J.C.,Stewart, A. Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21:209-219, 2013 Cited by PubMed: 23273428 DOI: 10.1016/j.str.2012.11.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation